Literature DB >> 24015152

Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.

Shaodong Guo1.   

Abstract

Insulin/IGF-1 signaling plays a central role in control of cellular metabolism and survival, while insulin receptor substrate (IRS) protein -1 and -2 and downstream PI-3 kinase→Akt→Foxo1 signaling cascade play key roles in many functions of insulin/IGF-1. Dysregulation of this branch of signaling cascades may provide a mechanism for insulin resistance as we observed in cells, animals, and even humans. Targeting this branch of IRS→Foxo1 signaling may provide us with fundamental strategies for drug development in the future.

Entities:  

Year:  2013        PMID： 24015152      PMCID： PMC3763863          DOI： 10.1016/j.ddmec.2013.06.003

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  53 in total

1.  Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets.

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Journal:  Drug Discov Today Dis Mech       Date:  2010

2.  FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.

Authors:  Kyoichiro Tsuchiya; Jun Tanaka; Yu Shuiqing; Carrie L Welch; Ronald A DePinho; Ira Tabas; Alan R Tall; Ira J Goldberg; Domenico Accili
Journal:  Cell Metab       Date:  2012-03-07       Impact factor: 27.287

3.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

Authors:  E Araki; M A Lipes; M E Patti; J C Brüning; B Haag; R S Johnson; C R Kahn
Journal:  Nature       Date:  1994-11-10       Impact factor: 49.962

4.  Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.

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Journal:  J Biol Chem       Date:  1999-06-11       Impact factor: 5.157

5.  Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.

Authors:  Yun Chau Long; Zhiyong Cheng; Kyle D Copps; Morris F White
Journal:  Mol Cell Biol       Date:  2010-12-06       Impact factor: 4.272

6.  RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium.

Authors:  Angela F Messmer-Blust; Melissa J Philbrick; Shuzhen Guo; Jiaping Wu; Ping He; Shaodong Guo; Jian Li
Journal:  Circ Res       Date:  2012-07-25       Impact factor: 17.367

7.  A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.

Authors:  J C Brüning; M D Michael; J N Winnay; T Hayashi; D Hörsch; D Accili; L J Goodyear; C R Kahn
Journal:  Mol Cell       Date:  1998-11       Impact factor: 17.970

8.  Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Authors:  Chutima Talchai; Shouhong Xuan; Hua V Lin; Lori Sussel; Domenico Accili
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

9.  IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.

Authors:  Marianna Sadagurski; Rebecca L Leshan; Christa Patterson; Aldo Rozzo; Alexandra Kuznetsova; Josh Skorupski; Justin C Jones; Ronald A Depinho; Martin G Myers; Morris F White
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

10.  The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.

Authors:  Leona Plum; Hua V Lin; Roxanne Dutia; Jun Tanaka; Kumiko S Aizawa; Michihiro Matsumoto; Andrea J Kim; Niamh X Cawley; Ji-Hye Paik; Y Peng Loh; Ronald A DePinho; Sharon L Wardlaw; Domenico Accili
Journal:  Nat Med       Date:  2009-09-20       Impact factor: 53.440
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  24 in total

1.  Control of hyperglycemia in male mice by leflunomide: mechanisms of action.

Authors:  Junhong Chen; Jing Sun; Michelle E Doscas; Jin Ye; Ashley J Williamson; Yanchun Li; Yi Li; Richard A Prinz; Xiulong Xu
Journal:  J Endocrinol       Date:  2018-04       Impact factor: 4.286

2.  Mechanisms of Heart Failure in Type 2 Diabetes Mellitus.

Authors:  Shaodong Guo
Journal:  Austin J Clin Cardiol       Date:  2014

3.  Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.

Authors:  Yunhua L Muller; Michael Saporito; Samantha Day; Khushdeep Bandesh; Cigdem Koroglu; Sayuko Kobes; William C Knowler; Robert L Hanson; Cristopher V Van Hout; Alan R Shuldiner; Clifton Bogardus; Leslie J Baier
Journal:  Eur J Hum Genet       Date:  2022-06-10       Impact factor: 5.351

Review 4.  Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.

Authors:  Shaodong Guo
Journal:  J Endocrinol       Date:  2014-01-08       Impact factor: 4.286

5.  Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

Authors:  Yajuan Qi; Zihui Xu; Qinglei Zhu; Candice Thomas; Rajesh Kumar; Hao Feng; David E Dostal; Morris F White; Kenneth M Baker; Shaodong Guo
Journal:  Diabetes       Date:  2013-11       Impact factor: 9.461

6.  IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.

Authors:  Chen-Yi Tang; Xiao-Fei Man; Yue Guo; Hao-Neng Tang; Jun Tang; Ci-La Zhou; Shu-Wen Tan; Min Wang; Hou-De Zhou
Journal:  Mol Cells       Date:  2017-02-13       Impact factor: 5.034

7.  Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice.

Authors:  Sung-Hsun Yu; Szu-Yu Tina Chen; Wei-Shan Li; Navneet Kumar Dubey; Wei-Hong Chen; Jiunn-Jye Chuu; Sy-Jye Leu; Win-Ping Deng
Journal:  J Diabetes Res       Date:  2015-07-16       Impact factor: 4.011

8.  Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.

Authors:  Yue Hu; Min Zhou; Kai Zhang; Xiangquan Kong; Xiaoyan Hu; Kang Li; Li Liu
Journal:  PLoS One       Date:  2014-01-30       Impact factor: 3.240

9.  Cardiometabolic risk profiles associated with chronic complications in overweight and obese type 2 diabetes patients in South China.

Authors:  Yanzhen Cheng; Hua Zhang; Rongping Chen; Fan Yang; Wei Li; Lishu Chen; Shaoda Lin; Ganxiong Liang; Dehong Cai; Hong Chen
Journal:  PLoS One       Date:  2014-07-03       Impact factor: 3.240

10.  Associations between Forkhead Box O1 (FoxO1) Expression and Indicators of Hepatic Glucose Production in Transition Dairy Cows Supplemented with Dietary Nicotinic Acid.

Authors:  Asako Kinoshita; Lena Locher; Reka Tienken; Ulrich Meyer; Sven Dänicke; Jürgen Rehage; Korinna Huber
Journal:  PLoS One       Date:  2016-01-22       Impact factor: 3.240
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