Proliferative vitreoretinopathy shows predilection for the inferior fundus.

We reviewed 112 consecutive cases of retinal detachment associated with grade C-1 proliferative vitreoretinopathy (PVR) to assess the initial location of the full-thickness retinal folds. A total of 47 eyes had PVR preoperatively, and 65 eyes demonstrated PVR postoperatively. Of the eyes affected preoperatively, 29 (56%) developed PVR in the inferior retina, as did 58 (74%) of the eyes affected postoperatively for a total of 87 eyes (67%). Eyes treated with cryoretinopexy had a higher incidence of PVR in the inferior retina (87.5%) than did those undergoing diathermy (57.6%) or photocoagulation (80%). Our findings suggested that the location of PVR may be influenced clinically by gravity. This tendency was more apparent after surgery, especially after cryoretinopexy, than preoperatively.