Literature DB >> 24011882

Type 2 diabetes and cognitive compromise: potential roles of diabetes-related therapies.

Efrat Kravitz1, James Schmeidler, Michal Schnaider Beeri.   

Abstract

Type 2 diabetes, like dementia, disproportionately affects the elderly. Diabetes has consistently been associated with risk of dementia, mild cognitive impairment, and cognitive decline suggesting that cognitive compromise is a deleterious manifestation of diabetes. This review summarizes observational studies and clinical trials of diabetes medications and their respective associations and effects on cognitive outcomes. Despite biological plausibility, results from most human clinical trials have failed to show any efficacy in treating Alzheimer disease symptomatology and pathology. Clinical trials targeting vascular-related outcomes, diabetic patients, or cognitively normal elderly at risk for dementia, may provide greater cognitive benefits.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer disease; Cognitive decline; Dementia; Insulin; Insulin resistance; Oral hypoglycemics; Type 2 diabetes

Mesh：

Substances：

Year:  2013        PMID： 24011882      PMCID： PMC3767929          DOI： 10.1016/j.ecl.2013.05.009

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  102 in total

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Journal:  Arch Neurol       Date:  1999-03

2.  The risk of dementia among persons with diabetes mellitus: a population-based cohort study.

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Journal:  Ann N Y Acad Sci       Date:  1997-09-26       Impact factor: 5.691

3.  Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys.

Authors:  Y Maeshiba; Y Kiyota; K Yamashita; Y Yoshimura; M Motohashi; S Tanayama
Journal:  Arzneimittelforschung       Date:  1997-01

4.  Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

Authors:  J M Lehmann; J M Lenhard; B B Oliver; G M Ringold; S A Kliewer
Journal:  J Biol Chem       Date:  1997-02-07       Impact factor: 5.157

Review 5.  Metformin.

Authors:  C J Bailey; R C Turner
Journal:  N Engl J Med       Date:  1996-02-29       Impact factor: 91.245

6.  Vascular risk factors, incidence of MCI, and rates of progression to dementia.

Authors:  V Solfrizzi; F Panza; A M Colacicco; A D'Introno; C Capurso; F Torres; F Grigoletto; S Maggi; A Del Parigi; E M Reiman; R J Caselli; E Scafato; G Farchi; A Capurso
Journal:  Neurology       Date:  2004-11-23       Impact factor: 9.910

7.  Frequency of stages of Alzheimer-related lesions in different age categories.

Authors:  H Braak; E Braak
Journal:  Neurobiol Aging       Date:  1997 Jul-Aug       Impact factor: 4.673

8.  Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study.

Authors:  Linda B Hassing; Michael D Grant; Scott M Hofer; Nancy L Pedersen; Sven E Nilsson; Stig Berg; Gerald McClearn; Boo Johansson
Journal:  J Int Neuropsychol Soc       Date:  2004-07       Impact factor: 2.892

9.  Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study.

Authors:  W L Xu; C X Qiu; A Wahlin; B Winblad; L Fratiglioni
Journal:  Neurology       Date:  2004-10-12       Impact factor: 9.910

10.  Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs.

Authors:  G D Baura; D M Foster; K Kaiyala; D Porte; S E Kahn; M W Schwartz
Journal:  Diabetes       Date:  1996-01       Impact factor: 9.461
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  15 in total

1.  Depression is more strongly associated with cognition in elderly women than men with type 2 diabetes.

Authors:  Laili Soleimani; Ramit Ravona-Springer; Anthony Heymann; Elizabeth Guerrero-Berroa; James Schmeidler; Ruth Zukran; Rachel Preiss; Jeremy M Silverman; Mary Sano; Michal Schnaider Beeri
Journal:  Int Psychogeriatr       Date:  2018-12-11       Impact factor: 3.878

2.  Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy.

Authors:  Lin Tian; Hong Ri; Jiping Qi; Peng Fu
Journal:  Mol Pain       Date:  2021 Jan-Dec       Impact factor: 3.395

Review 3.  Diabetes mellitus and cognitive impairments.

Authors:  Elham Saedi; Mohammad Reza Gheini; Firoozeh Faiz; Mohammad Ali Arami
Journal:  World J Diabetes       Date:  2016-09-15

4.  Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress.

Authors:  Wei-Ting Xuan; Han Wang; Peng Zhou; Ting Ye; Hua-Wu Gao; Shu Ye; Jing-Hui Wang; Meng-Lian Chen; Hang Song; Yan Wang; Biao Cai
Journal:  3 Biotech       Date:  2020-07-29       Impact factor: 2.406

5.  Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes.

Authors:  Laili Soleimani; Ramit Ravona-Springer; Hung-Mo Lin; Xiaoyu Liu; Mary Sano; Anthony Heymann; Michal Schnaider Beeri
Journal:  Diabetes Care       Date:  2021-01-19       Impact factor: 19.112

6.  Importance of Geriatric Syndromes in Older Patients with Diabetes with de novo Insulin Treatment: The VEGAS Study.

Authors:  Andrej Zeyfang; Andrea Patzelt-Bath
Journal:  Drugs Real World Outcomes       Date:  2015-03

7.  Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 diabetes patients and healthy controls.

Authors:  Yan-Feng Zhen; Xing-Yu Liu; Dong-Hao Zhou; Xiangdong Du; Guangzhong Yin; Yingyang Zhang; Hui Fang; Gang Xu; Jair C Soares; Xiang Yang Zhang
Journal:  Oncotarget       Date:  2017-12-16

8.  Strong Association between Plasma Dipeptidyl Peptidase-4 Activity and Impaired Cognitive Function in Elderly Population with Normal Glucose Tolerance.

Authors:  Bo Chen; Tianpeng Zheng; Linyuan Qin; Xueping Hu; Xiaoxi Zhang; Yihong Liu; Hongbo Liu; Shenghua Qin; Gang Li; Qinghua Li
Journal:  Front Aging Neurosci       Date:  2017-07-26       Impact factor: 5.750

9.  Aberrant Brain Regional Homogeneity and Functional Connectivity in Middle-Aged T2DM Patients: A Resting-State Functional MRI Study.

Authors:  Daihong Liu; Shanshan Duan; Jiuquan Zhang; Chaoyang Zhou; Minglong Liang; Xuntao Yin; Ping Wei; Jian Wang
Journal:  Front Hum Neurosci       Date:  2016-09-27       Impact factor: 3.169

Review 10.  Drug therapies for chronic conditions and risk of Alzheimer's disease and related dementias: A scoping review.

Authors:  Johanna Thunell; Yi Chen; Geoffrey Joyce; Douglas Barthold; Paul G Shekelle; Roberta Diaz Brinton; Julie Zissimopoulos
Journal:  Alzheimers Dement       Date:  2020-10-08       Impact factor: 21.566
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