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Literature DB >> 24011512

Unlocking the biology of RAGE in diabetic microvascular complications.

Michaele B Manigrasso¹, Judyta Juranek¹, Ravichandran Ramasamy¹, Ann Marie Schmidt².

Abstract

The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for the elucidation of important mechanisms underpinning diabetic complications. RAGE transduces the signals of advanced glycation end-products (AGEs), proinflammatory S100/calgranulins, and high mobility group box 1 (HMGB1), and is a one of a family of receptors for lysophosphatidic acid (LPA). These ligand tales weave a theme of vascular perturbation and inflammation linked to the pathogenesis of the chronic complications of diabetes. Once deemed implausible, this concept of inflammatory cues participating in diabetic complications is now supported by a plethora of experimental evidence in the macro- and microvasculature. We review the biology of ligand-RAGE signal transduction and its roles in diabetic microvascular complications, from animal models to human subjects.

Entities: Chemical Disease Gene Species

Keywords: complications; diabetes; inflammation; ligands; receptor for AGE

Mesh：

Substances：

Year: 2013 PMID： 24011512 PMCID： PMC3877224 DOI： 10.1016/j.tem.2013.08.002

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

88 in total

1. Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats.

Authors: Kellie McCormick Hallam; Qing Li; Radha Ananthakrishnan; Anastasia Kalea; Yu S Zou; Srinivasan Vedantham; Ann Marie Schmidt; Shi Fang Yan; Ravichandran Ramasamy
Journal: Aging Cell Date: 2010-08-15 Impact factor: 9.304

2. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose.

Authors: P J Thornalley; A Langborg; H S Minhas
Journal: Biochem J Date: 1999-11-15 Impact factor: 3.857

3. Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury.

Authors: Masayuki Shibasaki; Mika Sasaki; Mayumi Miura; Keiko Mizukoshi; Hiroshi Ueno; Satoru Hashimoto; Yoshifumi Tanaka; Fumimasa Amaya
Journal: Pain Date: 2010-04-13 Impact factor: 6.961

4. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.

Authors: Nozomu Tanji; Glen S Markowitz; Caifeng Fu; Thomas Kislinger; Akihiko Taguchi; Monika Pischetsrieder; David Stern; Ann Marie Schmidt; Vivette D D'Agati
Journal: J Am Soc Nephrol Date: 2000-09 Impact factor: 10.121

5. Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients.

Authors: Mohsen Kerkeni; Amel Saïdi; Hassan Bouzidi; Ahmed Letaief; Salim Ben Yahia; Mohamed Hammami
Journal: Diab Vasc Dis Res Date: 2012-10-22 Impact factor: 3.291

6. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

Authors: A M Schmidt; O Hori; J X Chen; J F Li; J Crandall; J Zhang; R Cao; S D Yan; J Brett; D Stern
Journal: J Clin Invest Date: 1995-09 Impact factor: 14.808

7. Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42.

Authors: Barry I Hudson; Anastasia Z Kalea; Maria Del Mar Arriero; Evis Harja; Eric Boulanger; Vivette D'Agati; Ann Marie Schmidt
Journal: J Biol Chem Date: 2008-10-15 Impact factor: 5.157

Review 8. Mechanisms of islet amyloidosis toxicity in type 2 diabetes.

Authors: Andisheh Abedini; Ann Marie Schmidt
Journal: FEBS Lett Date: 2013-01-18 Impact factor: 4.124

9. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.

Authors: Caroline A Abbott; Rayaz A Malik; Ernest R E van Ross; Jai Kulkarni; Andrew J M Boulton
Journal: Diabetes Care Date: 2011-08-18 Impact factor: 19.112

Unlocking the biology of RAGE in diabetic microvascular complications.

1. Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats.

2. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose.

3. Induction of high mobility group box-1 in dorsal root ganglion contributes to pain hypersensitivity after peripheral nerve injury.

4. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.

5. Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients.

6. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

7. Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42.

Review 8. Mechanisms of islet amyloidosis toxicity in type 2 diabetes.

9. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.

10. Increasing incidence of type 1 diabetes in youth: twenty years of the Philadelphia Pediatric Diabetes Registry.

Review 1. Metabolic Regulation of Angiogenesis in Diabetes and Aging.

2. Impaired Recognition of Mycobacterium tuberculosis by Alveolar Macrophages From Diabetic Mice.

Review 3. DAMP-sensing receptors in sterile inflammation and inflammatory diseases.

Review 4. Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease.

Review 5. Chelation therapy to prevent diabetes-associated cardiovascular events.

Review 6. Role of HMGB1 signaling in the inflammatory process in diabetic retinopathy.

Review 7. Emerging roles of hematopoietic cells in the pathobiology of diabetic complications.

Review 8. Metabolism of stromal and immune cells in health and disease.

Review 9. Heavy Metals, Cardiovascular Disease, and the Unexpected Benefits of Chelation Therapy.

Review 10. Heart Failure in Type 2 Diabetes Mellitus.