Literature DB >> 24011066

Leptin, GABA, and glucose control.

Barbara B Kahn1, Yasuhiko Minokoshi.   

Abstract

Leptin mimics many of the antidiabetic actions of insulin in insulin-deficient diabetes, but the mechanism is controversial. Fujikawa et al. (2013) reveal that leptin receptors in γ-aminobutyric acid (GABA)-ergic and pro-opiomelanocortin (POMC) neurons in the central nervous system are sufficient to mediate the lifesaving and antidiabetic actions of leptin in insulin-deficient mice.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24011066      PMCID： PMC4097301          DOI： 10.1016/j.cmet.2013.08.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  9 in total

1.  Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Authors:  Teppei Fujikawa; Eric D Berglund; Vishal R Patel; Giorgio Ramadori; Claudia R Vianna; Linh Vong; Fabrizio Thorel; Simona Chera; Pedro L Herrera; Bradford B Lowell; Joel K Elmquist; Pierre Baldi; Roberto Coppari
Journal:  Cell Metab       Date:  2013-09-03       Impact factor: 27.287

2.  Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats.

Authors:  Y Minokoshi; M S Haque; T Shimazu
Journal:  Diabetes       Date:  1999-02       Impact factor: 9.461

3.  Hypothalamic K(ATP) channels control hepatic glucose production.

Authors:  Alessandro Pocai; Tony K T Lam; Roger Gutierrez-Juarez; Silvana Obici; Gary J Schwartz; Joseph Bryan; Lydia Aguilar-Bryan; Luciano Rossetti
Journal:  Nature       Date:  2005-04-21       Impact factor: 49.962

4.  Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia.

Authors:  Jonathan P German; Joshua P Thaler; Brent E Wisse; Shinsuke Oh-I; David A Sarruf; Miles E Matsen; Jonathan D Fischer; Gerald J Taborsky; Michael W Schwartz; Gregory J Morton
Journal:  Endocrinology       Date:  2010-12-15       Impact factor: 4.736

5.  Leptin therapy in insulin-deficient type I diabetes.

Authors:  May-yun Wang; Lijun Chen; Gregory O Clark; Young Lee; Robert D Stevens; Olga R Ilkayeva; Brett R Wenner; James R Bain; Maureen J Charron; Christopher B Newgard; Roger H Unger
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-01       Impact factor: 11.205

Review 6.  Leptin and the central nervous system control of glucose metabolism.

Authors:  Gregory J Morton; Michael W Schwartz
Journal:  Physiol Rev       Date:  2011-04       Impact factor: 37.312

7.  Antidiabetic effects of IGFBP2, a leptin-regulated gene.

Authors:  Kristina Hedbacker; Kivanç Birsoy; Robert W Wysocki; Esra Asilmaz; Rexford S Ahima; I Sadaf Farooqi; Jeffrey M Friedman
Journal:  Cell Metab       Date:  2010-01       Impact factor: 27.287

8.  GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure.

Authors:  Dong Kong; Qingchun Tong; Chianping Ye; Shuichi Koda; Patrick M Fuller; Michael J Krashes; Linh Vong; Russell S Ray; David P Olson; Bradford B Lowell
Journal:  Cell       Date:  2012-10-26       Impact factor: 41.582

9.  Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia.

Authors:  Thomas H Meek; Miles E Matsen; Mauricio D Dorfman; Stephan J Guyenet; Vincent Damian; Hong T Nguyen; Gerald J Taborsky; Gregory J Morton
Journal:  Endocrinology       Date:  2013-06-19       Impact factor: 4.736
  9 in total
  4 in total

1.  Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.

Authors:  Mehdi Farokhnia; Mikela B Sheskier; Mary R Lee; April N Le; Erick Singley; Sofia Bouhlal; Timmy Ton; Zhen Zhao; Lorenzo Leggio
Journal:  Neuropharmacology       Date:  2018-04-14       Impact factor: 5.250

Review 2.  Leptin and psychiatric illnesses: does leptin play a role in antipsychotic-induced weight gain?

Authors:  Francky Teddy Endomba; Aurel T Tankeu; Jan René Nkeck; Joel Noutakdie Tochie
Journal:  Lipids Health Dis       Date:  2020-02-07       Impact factor: 3.876

Review 3.  The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome in Children.

Authors:  Mark R Libowitz; Erika L Nurmi
Journal:  Front Psychiatry       Date:  2021-03-12       Impact factor: 4.157

Review 4.  Effects of the POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes.

Authors:  Dan Yang; Xintong Hou; Guimei Yang; Mengnan Li; Jian Zhang; Minmin Han; Yi Zhang; Yunfeng Liu
Journal:  Diabetes Metab Syndr Obes       Date:  2022-09-25       Impact factor: 3.249
  4 in total

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