| Literature DB >> 24009392 |
Shunsuke Kuroki1, Shogo Matoba, Mika Akiyoshi, Yasuko Matsumura, Hitoshi Miyachi, Nathan Mise, Kuniya Abe, Atsuo Ogura, Dagmar Wilhelm, Peter Koopman, Masami Nozaki, Yoshiakira Kanai, Yoichi Shinkai, Makoto Tachibana.
Abstract
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.Entities:
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Year: 2013 PMID： 24009392 DOI： 10.1126/science.1239864
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728