Literature DB >> 24004542

Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder.

Ali Sazci1, Mavi Deniz Ozel, Emel Ergul, Mehmet Emin Onder.   

Abstract

Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (χ(2)=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease.
© 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Association; Bipolar disorder; CI; Gender; HWE; Hardy–Weinberg equilibrium; MTHFR; NNMT; NNMT gene; OR; PAGE; PCR; PCR-RFLP; Turkey; confidence interval; methylenetetrahyrofolate reductase; nicotinamide-N-methyltransferase; odds ratio; polyacrylamide gel electrophoresis; polymerase chain reaction; polymerase chain reaction-restriction fragment length polymorphism; rs694539

Mesh：

Substances：

Year:  2013        PMID： 24004542     DOI： 10.1016/j.gene.2013.08.077

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

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7.  Lower serum nicotinamide N-methyltransferase levels in patients with bipolar disorder during acute episodes compared to healthy controls: a cross-sectional study.

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  10 in total

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