BACKGROUND: South Asians have increased risk for type-2 diabetes and cardiovascular disease, but the relationship between metabolic health and weight has not been described. This study establishes the prevalence of metabolic abnormalities in normal weight, overweight, and obese South Asians. METHODS: Participants were categorized by body mass index and waist circumference. Subjects with two or more cardiometabolic risk factors (blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and C-reactive protein) were defined as metabolically abnormal. RESULTS: Forty-one percent of the sample (n=1015) was metabolically abnormal, and 12% of those were normal weight. Of metabolically healthy individuals, 58% were overweight or obese. At a normal level of adiposity, women were more likely to be metabolically unhealthy, whereas men were more likely to be unhealthy with increasing adiposity. CONCLUSIONS: Similar to other ethnic groups, a significant number of normal weight South Asians can be metabolically unhealthy.
BACKGROUND: South Asians have increased risk for type-2 diabetes and cardiovascular disease, but the relationship between metabolic health and weight has not been described. This study establishes the prevalence of metabolic abnormalities in normal weight, overweight, and obese South Asians. METHODS:Participants were categorized by body mass index and waist circumference. Subjects with two or more cardiometabolic risk factors (blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and C-reactive protein) were defined as metabolically abnormal. RESULTS: Forty-one percent of the sample (n=1015) was metabolically abnormal, and 12% of those were normal weight. Of metabolically healthy individuals, 58% were overweight or obese. At a normal level of adiposity, women were more likely to be metabolically unhealthy, whereas men were more likely to be unhealthy with increasing adiposity. CONCLUSIONS: Similar to other ethnic groups, a significant number of normal weight South Asians can be metabolically unhealthy.
Authors: K G M M Alberti; Robert H Eckel; Scott M Grundy; Paul Z Zimmet; James I Cleeman; Karen A Donato; Jean-Charles Fruchart; W Philip T James; Catherine M Loria; Sidney C Smith Journal: Circulation Date: 2009-10-05 Impact factor: 29.690
Authors: Annaswamy Raji; Marie D Gerhard-Herman; Mercedes Warren; Stuart G Silverman; Vassilios Raptopoulos; Christos S Mantzoros; Donald C Simonson Journal: J Clin Endocrinol Metab Date: 2004-08 Impact factor: 5.958
Authors: Shivani A Patel; Roopa Shivashankar; Mohammed K Ali; R M Anjana; M Deepa; Deksha Kapoor; Dimple Kondal; Garima Rautela; V Mohan; K M Venkat Narayan; M Masood Kadir; Zafar Fatmi; Dorairaj Prabhakaran; Nikhil Tandon Journal: Glob Heart Date: 2016-03
Authors: Carlos A Gutiérrez-Rojas; Ruth Cruz-Soto; Verónica Sánchez-Muñoz; Anayeli Romero; Maureen Mosti-Molina; Hugo A Sánchez-Aguilar; David Velázquez-Fernández; Miguel F Herrera Journal: Obes Surg Date: 2020-04 Impact factor: 4.129
Authors: Shahin Jaffer; Heather J A Foulds; Monica Parry; Christine A Gonsalves; Christine Pacheco; Marie-Annick Clavel; Kerri A Mullen; Cindy Y Y Yip; Sharon L Mulvagh; Colleen M Norris Journal: CJC Open Date: 2020-10-15