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Literature DB >> 2400219

Adrenal function in asthma.

K Priftis¹, A D Milner, E Conway, J W Honour.

Abstract

A dose dependent suppression of daily cortisol excretion was shown in 25 children with asthma being treated with beclomethasone dipropionate. Cortisol metabolites tended to occur below the normal range when doses of beclomethasone of more than 400 micrograms/m2/day were given. Androgen excretion below the normal range was apparent in asthmatic children aged 8-13 years regardless of whether they were receiving inhaled steroids. This may be the reason for growth delay often seen in asthmatic children. These side effects of beclomethasone are not enough reason to discourage its prescription for the treatment of asthma, but endocrine assessment is desirable when the dose exceeds 400 micrograms/m2/day.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1990 PMID： 2400219 PMCID： PMC1792501 DOI： 10.1136/adc.65.8.838

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

21 in total

1. Growth and childhood asthma.

Authors: L Balfour-Lynn
Journal: Arch Dis Child Date: 1986-11 Impact factor: 3.791

2. Treatment of chronic childhood asthma with beclomethasone dipropionate aerosol: I. A double-blind crossover trial in nonsteroid-dependent patients.

Authors: R Klein; D Waldman; H Kershnar; W Berger; A Coulson; R M Katz; G S Rachelefsky; S C Siegel
Journal: Pediatrics Date: 1977-07 Impact factor: 7.124

3. Aerosol beclomethasone dipropionate: a dose-response study in chronic bronchial asthma.

Authors: J Gaddie; G R Petrie; I W Reid; C Skinner; D J Sinclair; K N Palmer
Journal: Lancet Date: 1973-08-11 Impact factor: 79.321

4. Nocturnal adrenal suppression in children inhaling beclomethasone dipropionate.

Authors: C M Law; M A Preece; J O Warner
Journal: Lancet Date: 1987-06-06 Impact factor: 79.321

5. Chronic asthma and growth failure in children.

Authors: A B Murray; B M Fraser; D F Hardwick; G E Pirie
Journal: Lancet Date: 1976-07-24 Impact factor: 79.321

6. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. I.

Authors: J M Tanner; R H Whitehouse; M Takaishi
Journal: Arch Dis Child Date: 1966-10 Impact factor: 3.791

Review 7. Profiling steroid hormones and urinary steroids.

Authors: C H Shackleton
Journal: J Chromatogr Date: 1986-06-20

8. Comparison of two high dose corticosteroid aerosol treatments, beclomethasone dipropionate (1500 micrograms/day) and budesonide (1600 micrograms/day), for chronic asthma.

Authors: P Ebden; A Jenkins; G Houston; B H Davies
Journal: Thorax Date: 1986-11 Impact factor: 9.139

9. Childhood asthma and growth outcome.

Authors: M Shohat; T Shohat; R Kedem; M Mimouni; Y L Danon
Journal: Arch Dis Child Date: 1987-01 Impact factor: 3.791

10. Effect of androgen on growth hormone secretion and growth in boys with short stature.

Authors: L G Martin; M S Grossman; T B Connor; L L Levitsky; J W Clark; F D Camitta
Journal: Acta Endocrinol (Copenh) Date: 1979-06

20 in total

1. Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjects.

Authors: T W Harrison; A Wisniewski; J Honour; A E Tattersfield
Journal: Thorax Date: 2001-03 Impact factor: 9.139

Review 2. Asthma: a follow up statement from an international paediatric asthma consensus group.

Authors:
Journal: Arch Dis Child Date: 1992-02 Impact factor: 3.791

Review 3. Very high dose inhaled corticosteroids: panacea or poison?

Authors: G Russell
Journal: Arch Dis Child Date: 2006-10 Impact factor: 3.791

4. Growth of asthmatic children.

Authors:
Journal: BMJ Date: 1991-08-17

Review 5. Asthma treatment and growth.

Authors: N J Shaw; N C Fraser; P H Weller
Journal: Arch Dis Child Date: 1997-10 Impact factor: 3.791

Review 6. Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids.

Authors: B J Lipworth; J R Seckl
Journal: Thorax Date: 1997-05 Impact factor: 9.139

7. Adrenal function and high dose inhaled corticosteroids for asthma.

Authors: P K Yiallouros; A D Milner; E Conway; J W Honour
Journal: Arch Dis Child Date: 1997-05 Impact factor: 3.791

8. Linear growth in prepubertal children with atopic dermatitis.

Authors: L Patel; P E Clayton; G M Addison; D A Price; T J David
Journal: Arch Dis Child Date: 1998-08 Impact factor: 3.791

9. Comparison of the efficacy and safety of inhaled fluticasone propionate 200 micrograms/day with inhaled beclomethasone dipropionate 400 micrograms/day in mild and moderate asthma.

Authors: P Gustafsson; J Tsanakas; M Gold; R Primhak; M Radford; E Gillies
Journal: Arch Dis Child Date: 1993-08 Impact factor: 3.791

10. Unexpected side-effects of inhaled steroids: a case report.

Authors: K Priftis; M L Everard; A D Milner
Journal: Eur J Pediatr Date: 1991-04 Impact factor: 3.183