Literature DB >> 23999442

Glutamine and cancer: cell biology, physiology, and clinical opportunities.

Christopher T Hensley1, Ajla T Wasti, Ralph J DeBerardinis.   

Abstract

Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23999442      PMCID： PMC3754270          DOI： 10.1172/JCI69600

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  81 in total

Review 1.  Gut glutamine metabolism.

Authors:  W W Souba; K Herskowitz; R M Salloum; M K Chen; T R Austgen
Journal:  JPEN J Parenter Enteral Nutr       Date:  1990 Jul-Aug       Impact factor: 4.016

2.  Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Authors:  L J Reitzer; B M Wice; D Kennell
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

Review 3.  Role of glutamine in cancer: therapeutic and imaging implications.

Authors:  Kartik N Rajagopalan; Ralph J DeBerardinis
Journal:  J Nucl Med       Date:  2011-06-16       Impact factor: 10.057

Review 4.  Recent advances in neuroblastoma.

Authors:  John M Maris
Journal:  N Engl J Med       Date:  2010-06-10       Impact factor: 91.245

5.  Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.

Authors:  Andrew Y Choo; Sang Gyun Kim; Matthew G Vander Heiden; Sarah J Mahoney; Hieu Vu; Sang-Oh Yoon; Lewis C Cantley; John Blenis
Journal:  Mol Cell       Date:  2010-05-28       Impact factor: 17.970

6.  PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.

Authors:  Brian P Lieberman; Karl Ploessl; Limin Wang; Wenchao Qu; Zhihao Zha; David R Wise; Lewis A Chodosh; George Belka; Craig B Thompson; Hank F Kung
Journal:  J Nucl Med       Date:  2011-11-15       Impact factor: 10.057

7.  Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709).

Authors:  Judith G Villablanca; Mark D Krailo; Matthew M Ames; Joel M Reid; Gregory H Reaman; C Patrick Reynolds; Patrick C Reynolds
Journal:  J Clin Oncol       Date:  2006-07-20       Impact factor: 44.544

8.  The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Authors:  Mariia O Yuneva; Teresa W M Fan; Thaddeus D Allen; Richard M Higashi; Dana V Ferraris; Takashi Tsukamoto; José M Matés; Francisco J Alonso; Chunmei Wang; Youngho Seo; Xin Chen; J Michael Bishop
Journal:  Cell Metab       Date:  2012-02-08       Impact factor: 27.287

Review 9.  How cancer metabolism is tuned for proliferation and vulnerable to disruption.

Authors:  Almut Schulze; Adrian L Harris
Journal:  Nature       Date:  2012-11-15       Impact factor: 49.962

10.  Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man.

Authors:  T Brundin; J Wahren
Journal:  Am J Physiol       Date:  1994-11
View more
  451 in total

1.  Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non-Small Cell Lung Cancer and Its Potential as a Circulating Biomarker.

Authors:  Tzu-Fang Lou; Deepa Sethuraman; Patrick Dospoy; Pallevi Srivastva; Hyun Seok Kim; Joongsoo Kim; Xiaotu Ma; Pei-Hsuan Chen; Kenneth E Huffman; Robin E Frink; Jill E Larsen; Cheryl Lewis; Sang-Won Um; Duk-Hwan Kim; Jung-Mo Ahn; Ralph J DeBerardinis; Michael A White; John D Minna; Hyuntae Yoo
Journal:  Cancer Prev Res (Phila)       Date:  2015-10-28

2.  Exploiting tumor metabolism: challenges for clinical translation.

Authors:  Matthew G Vander Heiden
Journal:  J Clin Invest       Date:  2013-09-03       Impact factor: 14.808

Review 3.  The Evolving AML Genomic Landscape: Therapeutic Implications.

Authors:  Sachi Horibata; George Alyateem; Christin B DeStefano; Michael M Gottesman
Journal:  Curr Cancer Drug Targets       Date:  2020       Impact factor: 3.428

4.  Large-scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival.

Authors:  Venkatrao Vantaku; Sri Ramya Donepudi; Danthasinghe Waduge Badrajee Piyarathna; Chandra Sekhar Amara; Chandrashekar R Ambati; Wei Tang; Vasanta Putluri; Darshan S Chandrashekar; Sooryanarayana Varambally; Martha K Terris; Kimberly Davies; Stefan Ambs; Roni Bollag; Andrea B Apolo; Arun Sreekumar; Nagireddy Putluri
Journal:  Cancer       Date:  2019-01-02       Impact factor: 6.860

5.  p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

Authors:  Hilaire C Lam; Christian V Baglini; Alicia Llorente Lope; Andrey A Parkhitko; Heng-Jia Liu; Nicola Alesi; Izabela A Malinowska; Darius Ebrahimi-Fakhari; Afshin Saffari; Jane J Yu; Ana Pereira; Damir Khabibullin; Barbara Ogorek; Julie Nijmeh; Taylor Kavanagh; Adam Handen; Stephen Y Chan; John M Asara; William M Oldham; Maria T Diaz-Meco; Jorge Moscat; Mustafa Sahin; Carmen Priolo; Elizabeth P Henske
Journal:  Cancer Res       Date:  2017-05-16       Impact factor: 12.701

Review 6.  MYC, Metabolism, and Cancer.

Authors:  Zachary E Stine; Zandra E Walton; Brian J Altman; Annie L Hsieh; Chi V Dang
Journal:  Cancer Discov       Date:  2015-09-17       Impact factor: 39.397

Review 7.  The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension.

Authors:  Thomas Bertero; Dror Perk; Stephen Y Chan
Journal:  Expert Opin Ther Targets       Date:  2019-05-11       Impact factor: 6.902

8.  Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI.

Authors:  Kejia Cai; He N Xu; Anup Singh; Lily Moon; Mohammad Haris; Ravinder Reddy; Lin Z Li
Journal:  Mol Imaging Biol       Date:  2014-10       Impact factor: 3.488

9.  Understanding tumor anabolism and patient catabolism in cancer-associated cachexia.

Authors:  Alejandro Schcolnik-Cabrera; Alma Chávez-Blanco; Guadalupe Domínguez-Gómez; Alfonso Dueñas-González
Journal:  Am J Cancer Res       Date:  2017-05-01       Impact factor: 6.166

10.  Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

Authors:  Yan Xiang; Zachary E Stine; Jinsong Xia; Yunqi Lu; Roddy S O'Connor; Brian J Altman; Annie L Hsieh; Arvin M Gouw; Ajit G Thomas; Ping Gao; Linchong Sun; Libing Song; Benedict Yan; Barbara S Slusher; Jingli Zhuo; London L Ooi; Caroline G L Lee; Anthony Mancuso; Andrew S McCallion; Anne Le; Michael C Milone; Stephen Rayport; Dean W Felsher; Chi V Dang
Journal:  J Clin Invest       Date:  2015-04-27       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.