Sheona M Mitchell1, Musa Sekikubo2, Christine Biryabarema2, Josaphat J K Byamugisha2, Malcolm Steinberg3, Jose Jeronimo4, Deborah M Money5, Jan Christilaw6, Gina S Ogilvie7. 1. Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada. 2. Department of Obstetrics and Gynecology, Mulago Hospital, Makerere University, Kampala, Uganda. 3. British Columbia Center for Disease Control, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada. 4. Program for Appropriate Technology in Health, Seattle, WA. 5. Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia's Women's Hospital, Vancouver, British Columbia, Canada. 6. British Columbia's Women's Hospital, Vancouver, British Columbia, Canada. 7. Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Center for Disease Control, Vancouver, British Columbia, Canada. Electronic address: gina.ogilvie@bccdc.ca.
Abstract
OBJECTIVE: We sought to determine demographic and behavioral factors associated with human papillomavirus (HPV) positivity in a community-based HPV self-collection cervical cancer screening pilot project. STUDY DESIGN: HPV self-collected samples were obtained from 199 women aged 30-69 years in the impoverished urban Ugandan community of Kisenyi, during September through November 2011. Demographic and behavioral information was collected. Descriptive statistics and a logistic regression model were used to analyze factors associated with HPV positivity. RESULTS: There was overwhelming acceptance of HPV self-collection in this community. High-risk HPV prevalence was found to be 17.6%. Lower levels of formal education (adjusted odds ratio [AOR], 0.40; 95% confidence interval [CI], 0.08-2.03) were associated with higher prevalence of HPV as was use of oral contraception (AOR, 2.01; 95% CI, 0.83-4.90) and human immunodeficiency virus status (AOR, 0.43; 95% CI, 0.14-1.37). CONCLUSION: Screening should be targeted and prioritized for women with lower levels of education, oral contraceptive use, and human immunodeficiency virus positivity as they have the highest HPV prevalence in this low-resource population.
OBJECTIVE: We sought to determine demographic and behavioral factors associated with human papillomavirus (HPV) positivity in a community-based HPV self-collection cervical cancer screening pilot project. STUDY DESIGN:HPV self-collected samples were obtained from 199 women aged 30-69 years in the impoverished urban Ugandan community of Kisenyi, during September through November 2011. Demographic and behavioral information was collected. Descriptive statistics and a logistic regression model were used to analyze factors associated with HPV positivity. RESULTS: There was overwhelming acceptance of HPV self-collection in this community. High-risk HPV prevalence was found to be 17.6%. Lower levels of formal education (adjusted odds ratio [AOR], 0.40; 95% confidence interval [CI], 0.08-2.03) were associated with higher prevalence of HPV as was use of oral contraception (AOR, 2.01; 95% CI, 0.83-4.90) and human immunodeficiency virus status (AOR, 0.43; 95% CI, 0.14-1.37). CONCLUSION: Screening should be targeted and prioritized for women with lower levels of education, oral contraceptive use, and human immunodeficiency virus positivity as they have the highest HPV prevalence in this low-resource population.
Authors: Rachel L Winer; James P Hughes; Qinghua Feng; Joshua E Stern; Long Fu Xi; Laura A Koutsky Journal: J Infect Dis Date: 2016-03-23 Impact factor: 5.226
Authors: Sheona M Mitchell; Heather N Pedersen; Evelyn Eng Stime; Musa Sekikubo; Erin Moses; David Mwesigwa; Christine Biryabarema; Jan Christilaw; Josaphat K Byamugisha; Deborah M Money; Gina S Ogilvie Journal: BMC Womens Health Date: 2017-01-13 Impact factor: 2.809
Authors: Flora F Teng; Sheona M Mitchell; Musa Sekikubo; Christine Biryabarema; Josaphat K Byamugisha; Malcolm Steinberg; Deborah M Money; Gina S Ogilvie Journal: BMJ Open Date: 2014-04-11 Impact factor: 2.692
Authors: Sheona M Mitchell; Heather N Pedersen; Musa Sekikubo; Christine Biryabarema; Josaphat J K Byamugisha; David Mwesigwa; Malcolm Steinberg; Deborah M Money; Gina S Ogilvie Journal: Front Oncol Date: 2016-04-13 Impact factor: 6.244