Esther Tamayo1, Milagrosa Montes, José María García-Arenzana, Emilio Pérez-Trallero. 1. Microbiology Department, Hospital Universitario Donostia-Instituto Biodonostia, San Sebastián, Spain; Biomedical Research Centre Network for Respiratory Diseases (CIBERES), San Sebastián, Spain. Electronic address: esther.tamayooya@osakidetza.net.
Abstract
OBJECTIVE: To know the clinical entities caused by Streptococcus pyogenes as well as the characteristics of the isolates involved in them throughout a 7-year-study. METHODS: All S. pyogenes infectious episodes from the community recorded in the reference hospital of Gipuzkoa between 2005 and 2011 were included (n = 11,342). A random selection of 10% of total isolates was characterized by emm-type, T-type and multilocus-sequence-type. RESULTS: Main clinical presentations were: pharyngitis (n = 9467), otitis (n = 797), dermal infections (n = 506), and genital infections (n = 374). Highest frequency of pharyngitis and otitis was detected in children aged 2-8 years old and 1-year old, respectively. Among 29 emm-types, 8 (emm4, emm89, emm3, emm87, emm1, emm12, emm6 and emm75) grouped >70% of isolates. emm4 was significantly associated with 0-4 year-old patients, and emm89 and emm77 with patients >64 years; by infection type, emm4, emm87 and emm12 were associated with pharyngitis, emm1 and emm6 with otitis, emm89 with dermal infections, and emm77 with genital infections. CONCLUSIONS: Predominant emm-type changed every year, although the diversity was similar throughout the study period. S. pyogenes pharyngitis maximum incidence presented at earlier age than expected. emm-type associations with age and specific clinical presentations were influenced by population immunity and strain tropism.
OBJECTIVE: To know the clinical entities caused by Streptococcus pyogenes as well as the characteristics of the isolates involved in them throughout a 7-year-study. METHODS: All S. pyogenes infectious episodes from the community recorded in the reference hospital of Gipuzkoa between 2005 and 2011 were included (n = 11,342). A random selection of 10% of total isolates was characterized by emm-type, T-type and multilocus-sequence-type. RESULTS: Main clinical presentations were: pharyngitis (n = 9467), otitis (n = 797), dermal infections (n = 506), and genital infections (n = 374). Highest frequency of pharyngitis and otitis was detected in children aged 2-8 years old and 1-year old, respectively. Among 29 emm-types, 8 (emm4, emm89, emm3, emm87, emm1, emm12, emm6 and emm75) grouped >70% of isolates. emm4 was significantly associated with 0-4 year-old patients, and emm89 and emm77 with patients >64 years; by infection type, emm4, emm87 and emm12 were associated with pharyngitis, emm1 and emm6 with otitis, emm89 with dermal infections, and emm77 with genital infections. CONCLUSIONS: Predominant emm-type changed every year, although the diversity was similar throughout the study period. S. pyogenespharyngitis maximum incidence presented at earlier age than expected. emm-type associations with age and specific clinical presentations were influenced by population immunity and strain tropism.
Authors: F Koutouzi; A Tsakris; P Chatzichristou; E Koutouzis; G L Daikos; E Kirikou; N Petropoulou; V Syriopoulou; A Michos Journal: J Clin Microbiol Date: 2015-04-15 Impact factor: 5.948
Authors: Claire E Turner; James Abbott; Theresa Lamagni; Matthew T G Holden; Sophia David; Michael D Jones; Laurence Game; Androulla Efstratiou; Shiranee Sriskandan Journal: mBio Date: 2015-07-14 Impact factor: 7.867
Authors: Francesca Latronico; Waleed Nasser; Kai Puhakainen; Jukka Ollgren; Hanne-Leena Hyyryläinen; Stephen B Beres; Outi Lyytikäinen; Jari Jalava; James M Musser; Jaana Vuopio Journal: J Infect Dis Date: 2016-10-05 Impact factor: 5.226
Authors: Stephen B Beres; Randall J Olsen; Matthew Ojeda Saavedra; Roisin Ure; Arlene Reynolds; Diane S J Lindsay; Andrew J Smith; James M Musser Journal: J Med Microbiol Date: 2017-11-03 Impact factor: 2.472