Borah J Hong1, Brady Moffett2, William Payne3, Sundae Rich4, Elena C Ocampo3, Christopher J Petit5. 1. Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex. Electronic address: bjhong@texaschildrens.org. 2. Department of Pharmacy, Texas Children's Hospital, Houston, Tex. 3. Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex. 4. Department of Food and Nutrition Services, Texas Children's Hospital, Houston, Tex. 5. Division of Pediatric Cardiology, Department of Pediatrics, Children's Healthcare of Atlanta Sibley Heart Center, Emory University School of Medicine, Atlanta, Ga.
Abstract
OBJECTIVE: The study objective was to evaluate risk factors for poor weight gain in infants with hypoplastic left heart syndrome after stage 1 palliation. METHODS: We reviewed all term infants with hypoplastic left heart syndrome who had stage 1 palliation and stage 2 palliation at Texas Children's Hospital between 2000 and 2011 (n = 120). Predictor variables included age at stage 1 palliation, intensive care unit factors, calories delivered, and echocardiographic findings. Outcome variables included weight for age Z scores at hospital discharge, stage 2 palliation, and change in weight for age Z scores between stage 1 palliation and hospital discharge. RESULTS: Complete nutritional data were available for 47 of 120 patients. Median total parenteral nutrition duration was 6 days (range, 1-43 days), and median intensive care unit calories delivered was 53.9 kcal/kg/d (range, 22.3-119.6 kcal/kg/d). Before hospital discharge, the median caloric intake was 106.7 kcal/kg/d (range, 70.0-152.0 kcal/kg/d). Median weight for age Z scores was -0.59 (range, -3.6 to 0.5) at stage 1 palliation, -1.62 (range, -4.5 to -0.1) at intensive care unit transfer, and -1.81 (range, -4.9 to -0.5) at hospital discharge. A total of 46 of 47 patients had a negative change in weight for age Z scores between stage 1 palliation and hospital discharge, with a median change of -1.14 (range, -2.3 to 0.6). Change in weight for age Z scores from stage 1 palliation to discharge was directly associated with calories delivered and indirectly associated with hospital length of stay and moderate tricuspid regurgitation (P < .001). CONCLUSIONS: Postoperative nutrition fails to meet the needs of infants with hypoplastic left heart syndrome despite increased focus on nutritional support. Modifiable factors (eg, nutritional intake) and hemodynamic factors (eg, tricuspid regurgitation) may play roles in the poor weight gain of these infants.
OBJECTIVE: The study objective was to evaluate risk factors for poor weight gain in infants with hypoplastic left heart syndrome after stage 1 palliation. METHODS: We reviewed all term infants with hypoplastic left heart syndrome who had stage 1 palliation and stage 2 palliation at Texas Children's Hospital between 2000 and 2011 (n = 120). Predictor variables included age at stage 1 palliation, intensive care unit factors, calories delivered, and echocardiographic findings. Outcome variables included weight for age Z scores at hospital discharge, stage 2 palliation, and change in weight for age Z scores between stage 1 palliation and hospital discharge. RESULTS: Complete nutritional data were available for 47 of 120 patients. Median total parenteral nutrition duration was 6 days (range, 1-43 days), and median intensive care unit calories delivered was 53.9 kcal/kg/d (range, 22.3-119.6 kcal/kg/d). Before hospital discharge, the median caloric intake was 106.7 kcal/kg/d (range, 70.0-152.0 kcal/kg/d). Median weight for age Z scores was -0.59 (range, -3.6 to 0.5) at stage 1 palliation, -1.62 (range, -4.5 to -0.1) at intensive care unit transfer, and -1.81 (range, -4.9 to -0.5) at hospital discharge. A total of 46 of 47 patients had a negative change in weight for age Z scores between stage 1 palliation and hospital discharge, with a median change of -1.14 (range, -2.3 to 0.6). Change in weight for age Z scores from stage 1 palliation to discharge was directly associated with calories delivered and indirectly associated with hospital length of stay and moderate tricuspid regurgitation (P < .001). CONCLUSIONS: Postoperative nutrition fails to meet the needs of infants with hypoplastic left heart syndrome despite increased focus on nutritional support. Modifiable factors (eg, nutritional intake) and hemodynamic factors (eg, tricuspid regurgitation) may play roles in the poor weight gain of these infants.
Authors: Faith Ross; Gregory Latham; Denise Joffe; Michael Richards; Jeremy Geiduschek; Michael Eisses; Douglas Thompson; Monique Radman Journal: Cardiol Young Date: 2017-06-19 Impact factor: 1.093
Authors: Mehul D Patel; Karen Uzark; Sunkyung Yu; Janet Donohue; Sara K Pasquali; David Schidlow; David W Brown; Sarah Gelehrter Journal: Cardiol Young Date: 2015-01-02 Impact factor: 1.093
Authors: Jillian C Trabulsi; S Y Irving; M A Papas; C Hollowell; C Ravishankar; B S Marino; B Medoff-Cooper; J I Schall; V A Stallings Journal: Pediatr Cardiol Date: 2015-06-21 Impact factor: 1.655
Authors: George T Nicholson; Andrew C Glatz; Athar M Qureshi; Christopher J Petit; Jeffery J Meadows; Courtney McCracken; Michael Kelleman; Holly Bauser-Heaton; Ari J Gartenberg; R Allen Ligon; Varun Aggarwal; Derek B Kwakye; Bryan H Goldstein Journal: J Am Heart Assoc Date: 2019-12-19 Impact factor: 5.501
Authors: Esther van Puffelen; Jessie M Hulst; Ilse Vanhorebeek; Karolijn Dulfer; Greet Van den Berghe; Sascha C A T Verbruggen; Koen F M Joosten Journal: JAMA Netw Open Date: 2018-09-07