Literature DB >> 23998191

Allograft reconstruction for digital nerve loss.

John S Taras1, Nirav Amin, Nimit Patel, Lucy A McCabe.   

Abstract

PURPOSE: To investigate the outcomes of digital nerve repairs using processed nerve allograft for defects measuring 30 mm or less.
METHODS: Seventeen patients with 21 digital nerve lacerations in the hand underwent reconstruction with processed nerve allograft. Outcome data for 14 patients with 18 digital nerve lacerations were available for analysis. Postoperative outcome data were recorded at a minimum of 12 months and an average of 15 months. The average nerve gap measured 11 mm (range, 5-30 mm). Outcome measures included postoperative sensory examination as assessed by Semmes-Weinstein monofilaments and static and moving 2-point discrimination. Pain was graded using a visual analog scale throughout the recovery period. In addition, patients completed the Quick Disabilities of the Arm, Shoulder, and Hand survey before and after surgery.
RESULTS: Using Taras outcome criteria, 7 of 18 (39%) digits had excellent results, 8 of 18 (44%) had good results, 3 of 18 (17%) digits had fair results, and none had poor results. At final follow-up, Semmes-Weinstein monofilament testing results ranged from 0.08 g to 279 g. Quick Disabilities of the Arm, Shoulder, and Hand scores recorded at the patient's first postoperative visit averaged 45 (range, 2-80), and final scores averaged 26 (range, 2-43). There were no signs of infection, extrusion, or graft reaction.
CONCLUSIONS: The data suggest that processed nerve allograft provides a safe and effective alternative for the reconstruction of peripheral digital nerve deficits measuring up to 30 mm.
Copyright © 2013 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Allograft; digital nerve; nerve conduit; nerve reconstruction; peripheral nerve

Mesh:

Year:  2013        PMID: 23998191     DOI: 10.1016/j.jhsa.2013.07.008

Source DB:  PubMed          Journal:  J Hand Surg Am        ISSN: 0363-5023            Impact factor:   2.230


  18 in total

1.  A Multicenter, Prospective, Randomized, Pilot Study of Outcomes for Digital Nerve Repair in the Hand Using Hollow Conduit Compared With Processed Allograft Nerve.

Authors:  Kenneth R Means; Brian D Rinker; James P Higgins; S Houston Payne; Gregory A Merrell; E F Shaw Wilgis
Journal:  Hand (N Y)       Date:  2016-02-17

Review 2.  Clinical outcomes for Conduits and Scaffolds in peripheral nerve repair.

Authors:  David J Gerth; Jun Tashiro; Seth R Thaller
Journal:  World J Clin Cases       Date:  2015-02-16       Impact factor: 1.337

3.  Distal Digital Nerve Repair Using Nerve Allograft With a Dermal Substitute: A Case Report.

Authors:  Desirae McKee; Bradley Osemwengie; Cameron Cox
Journal:  Hand (N Y)       Date:  2019-06-04

4.  Implantation of Acellular Nerve Allograft Using Nerve Connectors.

Authors:  Jonathan Isaacs; Satya Mallu; Gaurangkumar Patel; Amy Kite; Sagar Shah; Gordon P Graham
Journal:  Hand (N Y)       Date:  2019-02-19

5.  Sensory Outcomes in Digital Nerve Repair Techniques: An Updated Meta-analysis and Systematic Review.

Authors:  Zachary J Herman; Asif M Ilyas
Journal:  Hand (N Y)       Date:  2019-05-01

6.  A Preliminary Assessment of the Utility of Large-Caliber Processed Nerve Allografts for the Repair of Upper Extremity Nerve Injuries.

Authors:  Jonathan Isaacs; Bauback Safa
Journal:  Hand (N Y)       Date:  2016-05-03

Review 7.  Nerve Repair with Nerve Conduits: Problems, Solutions, and Future Directions.

Authors:  Ryan Rebowe; Ashley Rogers; Xuebin Yang; S C Kundu; Thomas L Smith; Zhongyu Li
Journal:  J Hand Microsurg       Date:  2018-03-20

Review 8.  Overcoming short gaps in peripheral nerve repair: conduits and human acellular nerve allograft.

Authors:  Jonathan Isaacs; Timothy Browne
Journal:  Hand (N Y)       Date:  2014-06

Review 9.  Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration.

Authors:  Jian Du; Huanwen Chen; Liming Qing; Xiuli Yang; Xiaofeng Jia
Journal:  Biomater Sci       Date:  2018-05-29       Impact factor: 6.843

10.  One-stage human acellular nerve allograft reconstruction for digital nerve defects.

Authors:  Xue-Yuan Li; Hao-Liang Hu; Jian-Rong Fei; Xin Wang; Tian-Bing Wang; Pei-Xun Zhang; Hong Chen
Journal:  Neural Regen Res       Date:  2015-01       Impact factor: 5.135

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