Viruses associated with epizootic ulcerative syndrome: an update.

Epizootic ulcerative syndrome is one of the most serious infections noticed in the finfish of Asia-Pacific during the last three decades. Different viral agents and a consistent fungus were isolated from the EUS infected fishes from various countries. Rhabdoviruses are by far the most isolated group of viruses followed by birnaviruses. One reovirus and a ranavirus have also been isolated from ulcerated fishes of which the ranavirus was capable of reproducing the clinical signs of the disease. Albeit heterogenic, due to frequent isolation, range of areas from which isolates have been obtained and ability to induce dermal lesions in experimental infectivity studies make rhabdoviruses one of the likely primary aetiological agents that could be triggering the initiation to EUS. However, further investigations may be required to fully establish the role of these viral agents in the induction of EUS. Viruses observed as persistent infections in fishes evidenced by their presence in cell cultures also require further investigation for their likely role in predisposing the fishes to EUS.