Literature DB >> 23995579

One-pot total chemical synthesis of human α-synuclein.

Bruno Fauvet1, Sara M Butterfield, Jonas Fuks, Ashraf Brik, Hilal A Lashuel.   

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

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Year:  2013        PMID： 23995579     DOI： 10.1039/c3cc45353g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Authors:  Igor Dikiy; Bruno Fauvet; Ana Jovičić; Anne-Laure Mahul-Mellier; Carole Desobry; Farah El-Turk; Aaron D Gitler; Hilal A Lashuel; David Eliezer
Journal:  ACS Chem Biol       Date:  2016-07-11       Impact factor: 5.100

2.  EMBO conference series: Chemical Biology 2014.

Authors:  Eileen J Kennedy
Journal:  Chembiochem       Date:  2014-10-16       Impact factor: 3.164

Review 3.  Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins.

Authors:  Somasekhar Bondalapati; Muhammad Jbara; Ashraf Brik
Journal:  Nat Chem       Date:  2016-04-22       Impact factor: 24.427

4.  Improved chemical synthesis of hydrophobic Aβ peptides using addition of C-terminal lysines later removed by carboxypeptidase B.

Authors:  Saketh Chemuru; Ravindra Kodali; Ronald Wetzel
Journal:  Biopolymers       Date:  2014-03       Impact factor: 2.505

5.  Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein.

Authors:  Theodore A Sarafian; Kaitlyn Littlejohn; Sarah Yuan; Charlene Fernandez; Marianne Cilluffo; Bon-Kyung Koo; Julian P Whitelegge; Joseph B Watson
Journal:  J Neurosci Res       Date:  2017-01-24       Impact factor: 4.164

Review 6.  Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson disease and other synucleinopathies.

Authors:  Adrien W Schmid; Bruno Fauvet; Marc Moniatte; Hilal A Lashuel
Journal:  Mol Cell Proteomics       Date:  2013-08-21       Impact factor: 5.911

Review 7.  Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.

Authors:  Luis M A Oliveira; Thomas Gasser; Robert Edwards; Markus Zweckstetter; Ronald Melki; Leonidas Stefanis; Hilal A Lashuel; David Sulzer; Kostas Vekrellis; Glenda M Halliday; Julianna J Tomlinson; Michael Schlossmacher; Poul Henning Jensen; Julia Schulze-Hentrich; Olaf Riess; Warren D Hirst; Omar El-Agnaf; Brit Mollenhauer; Peter Lansbury; Tiago F Outeiro
Journal:  NPJ Parkinsons Dis       Date:  2021-07-26

Review 8.  Challenges and Perspectives in Chemical Synthesis of Highly Hydrophobic Peptides.

Authors:  Lena K Mueller; Andreas C Baumruck; Hanna Zhdanova; Alesia A Tietze
Journal:  Front Bioeng Biotechnol       Date:  2020-03-04

Review 9.  Consequences of post-translational modifications on amyloid proteins as revealed by protein semisynthesis.

Authors:  Stuart P Moon; Aaron T Balana; Matthew R Pratt
Journal:  Curr Opin Chem Biol       Date:  2021-06-25       Impact factor: 8.972
  9 in total

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