OBJECTIVE: Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryptamine (5-CT, a 5-HT1A/1B/1D/7R agonist) and/or SB-269970 (a selective 5-HT7R antagonist) immediately after the acquisition session of the novel object recognition test. MATERIALS AND METHODS: The object recognition test was performed in order to assess the effects of modulation of 5-HT7R during consolidation phase on episodic-like memory performances in mice. A protocol including 3 days of familiarisation to the apparatus has been realised in order to decrease the effect of novelty-induced arousal. RESULTS: With a 2-h delay, SB-269970 (3 and 10 mg/kg, administered subcutaneously) impaired the discrimination of the novel object. With a 4-h delay, while control mice were not able to discriminate the novel object, mice treated with 5-CT (1 mg/kg) showed a significant discrimination. This promnesic effect with a long delay is effectively mediated by 5-HT7R activation since it was blocked by SB-269970 (10 mg/kg), but not by WAY-100135 (10 mg/kg) or by GR-127935 (10 mg/kg). CONCLUSION: These data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition. Therefore, 5-HT7R could be a promising target to treat memory dysfunctions (especially episodically related deficits) related to normal or pathological ageing.
OBJECTIVE: Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryptamine (5-CT, a 5-HT1A/1B/1D/7R agonist) and/or SB-269970 (a selective 5-HT7R antagonist) immediately after the acquisition session of the novel object recognition test. MATERIALS AND METHODS: The object recognition test was performed in order to assess the effects of modulation of 5-HT7R during consolidation phase on episodic-like memory performances in mice. A protocol including 3 days of familiarisation to the apparatus has been realised in order to decrease the effect of novelty-induced arousal. RESULTS: With a 2-h delay, SB-269970 (3 and 10 mg/kg, administered subcutaneously) impaired the discrimination of the novel object. With a 4-h delay, while control mice were not able to discriminate the novel object, mice treated with 5-CT (1 mg/kg) showed a significant discrimination. This promnesic effect with a long delay is effectively mediated by 5-HT7R activation since it was blocked by SB-269970 (10 mg/kg), but not by WAY-100135 (10 mg/kg) or by GR-127935 (10 mg/kg). CONCLUSION: These data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition. Therefore, 5-HT7R could be a promising target to treat memory dysfunctions (especially episodically related deficits) related to normal or pathological ageing.
Authors: P J Lovell; S M Bromidge; S Dabbs; D M Duckworth; I T Forbes; A J Jennings; F D King; D N Middlemiss; S K Rahman; D V Saunders; L L Collin; J J Hagan; G J Riley; D R Thomas Journal: J Med Chem Date: 2000-02-10 Impact factor: 7.446
Authors: Valentine Bouet; Thomas Freret; Patrick Dutar; Jean-Marie Billard; Michel Boulouard Journal: Mech Ageing Dev Date: 2011-04-17 Impact factor: 5.432
Authors: Floriana Volpicelli; L Speranza; S Pulcrano; R De Gregorio; M Crispino; C De Sanctis; M Leopoldo; E Lacivita; U di Porzio; G C Bellenchi; C Perrone-Capano Journal: Mol Neurobiol Date: 2019-07-10 Impact factor: 5.590
Authors: Filippo Andreetta; Lucia Carboni; Gillian Grafton; Ross Jeggo; Andrew D Whyment; Marco van den Top; Daniel Hoyer; David Spanswick; Nicholas M Barnes Journal: Br J Pharmacol Date: 2016-03-21 Impact factor: 8.739
Authors: A Meneses; G Perez-Garcia; G Liy-Salmeron; T Ponce-López; E Lacivita; M Leopoldo Journal: Psychopharmacology (Berl) Date: 2014-07-31 Impact factor: 4.530