Literature DB >> 10669560

A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).

P J Lovell1, S M Bromidge, S Dabbs, D M Duckworth, I T Forbes, A J Jennings, F D King, D N Middlemiss, S K Rahman, D V Saunders, L L Collin, J J Hagan, G J Riley, D R Thomas.   

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Year:  2000        PMID： 10669560     DOI： 10.1021/jm991151j

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  47 in total

1.  [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.

Authors:  D R Thomas; P J Atkinson; M Ho; S M Bromidge; P J Lovell; A J Villani; J J Hagan; D N Middlemiss; G W Price
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

2.  High-affinity interactions of ligands at recombinant guinea pig 5HT7 receptors.

Authors:  R E Wilcox; J E Ragan; R S Pearlman; M Y Brusniak; R M Eglen; D W Bonhaus; T E Tenner; J D Miller
Journal:  J Comput Aided Mol Des       Date:  2001-10       Impact factor: 3.686

3.  5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum.

Authors:  Bishwa R Tuladhar; Lanbo Ge; Robert J Naylor
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

Review 4.  Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.

Authors:  Marcello Leopoldo; Enza Lacivita; Francesco Berardi; Roberto Perrone; Peter B Hedlund
Journal:  Pharmacol Ther       Date:  2010-10-20       Impact factor: 12.310

5.  Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines.

Authors:  Cécile Mahé; Michel Bernhard; Ionel Bobirnac; Corinna Keser; Erika Loetscher; Dominik Feuerbach; Kumlesh K Dev; Philippe Schoeffter
Journal:  Br J Pharmacol       Date:  2004-08-31       Impact factor: 8.739

6.  Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect.

Authors:  M T Klein; M Teitler
Journal:  Br J Pharmacol       Date:  2011-04       Impact factor: 8.739

7.  Modulation of 5-HT7 receptor: effect on object recognition performances in mice.

Authors:  Thomas Freret; Eleni Paizanis; Gregory Beaudet; Andreia Gusmao-Montaigne; Gerald Nee; François Dauphin; Valentine Bouet; Michel Boulouard
Journal:  Psychopharmacology (Berl)       Date:  2013-08-31       Impact factor: 4.530

Review 8.  Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.

Authors:  Anne Matthys; Guy Haegeman; Kathleen Van Craenenbroeck; Peter Vanhoenacker
Journal:  Mol Neurobiol       Date:  2011-03-22       Impact factor: 5.590

9.  Central 5-HT7 receptors are critical for reflex activation of cardiac vagal drive in anaesthetized rats.

Authors:  Daniel O Kellett; Andrew G Ramage; David Jordan
Journal:  J Physiol       Date:  2004-12-20       Impact factor: 5.182

10.  5-HT7 receptor efficacy distribution throughout the canine stomach.

Authors:  Pieter Janssen; Nicolaas H Prins; Pieter J Peeters; Klaas P Zuideveld; Romain A Lefebvre
Journal:  Br J Pharmacol       Date:  2004-08-31       Impact factor: 8.739
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