| Literature DB >> 23990352 |
Yan Sun1, Hua Tian, Lin Wang, Hui Yang.
Abstract
Colorectal cancer is the third most common malignancy worldwide. 5-fluorouracil (5-FU) is the commonly used chemotherapeutic agent, however, more patients develop resistance. Phosphatidylinositol 3-kinases (PI3Ks) play a crucial role in a wide range of cellular processes associated with malignant behavior including cell growth, migration, and survival. In this study, we show increased expression of PI3K p85α during the progression of colorectal cancer. Silencing of PI3K p85α in colorectal cancer cells increased disruption of mitochondrial membrane potential and enhanced 5-FU-induced apoptosis. Furthermore, PI3K p85α-depletion results in activated expression of apoptosis-associated genes Bcl-6, Bim, and Bax. Our results suggest that knockdown of PI3K p85α is a potential therapeutic strategy in the treatment of colorectal cancer.Entities:
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Year: 2013 PMID： 23990352 DOI： 10.1007/s12032-013-0704-7
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064