Liu Hong1, Yujie Zhang, Hongwei Zhang, Jianjun Yang, Qingchuan Zhao. 1. Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Electronic address: hongliu180@126.com.
Abstract
BACKGROUND: The incidence of esophagogastric junctional adenocarcinoma is increasing, and the surgery is associated with high mortality and morbidity rates. This study aims to evaluate whether three-field minimally invasive surgery promotes outcome as compared with three-incision open surgery. METHODS: From January 1, 2009, to March 1, 2012, 114 consecutive patients with Siewert typeI esophagogastric junctional adenocarcinoma were involved in this retrospective study. Patients were randomly assigned by a computer-generated randomization sequence to receive either three-incision open esophagectomy or minimally invasive esophagectomy. Details concerning patients and tumor characteristics, surgical procedures, and postoperative outcomes were collected and compared. RESULTS: Totally, 59 patients were involved in the open esophagectomy group and 55 in the minimally invasive esophagectomy group. The incidence of pulmonary morbidity (9.09% versus 28.81%) and vocal cord paralysis (0% versus 15.25%) in the minimally invasive group was significantly less than that in the open esophagectomy group. Furthermore, the postoperative life quality in the minimally invasive group was better than that in the open group. Survival at 2 years was 83.6% for the minimally invasive group (46 of 55 patients) and 79.7% for the open esophagectomy group (47 of 59 patients). CONCLUSIONS:Minimally invasive esophagectomy could lead to a significant improvement of the short-term benefits for patients with Siewert typeI esophagogastric junctional adenocarcinoma.
RCT Entities:
BACKGROUND: The incidence of esophagogastric junctional adenocarcinoma is increasing, and the surgery is associated with high mortality and morbidity rates. This study aims to evaluate whether three-field minimally invasive surgery promotes outcome as compared with three-incision open surgery. METHODS: From January 1, 2009, to March 1, 2012, 114 consecutive patients with Siewert type I esophagogastric junctional adenocarcinoma were involved in this retrospective study. Patients were randomly assigned by a computer-generated randomization sequence to receive either three-incision open esophagectomy or minimally invasive esophagectomy. Details concerning patients and tumor characteristics, surgical procedures, and postoperative outcomes were collected and compared. RESULTS: Totally, 59 patients were involved in the open esophagectomy group and 55 in the minimally invasive esophagectomy group. The incidence of pulmonary morbidity (9.09% versus 28.81%) and vocal cord paralysis (0% versus 15.25%) in the minimally invasive group was significantly less than that in the open esophagectomy group. Furthermore, the postoperative life quality in the minimally invasive group was better than that in the open group. Survival at 2 years was 83.6% for the minimally invasive group (46 of 55 patients) and 79.7% for the open esophagectomy group (47 of 59 patients). CONCLUSIONS: Minimally invasive esophagectomy could lead to a significant improvement of the short-term benefits for patients with Siewert type I esophagogastric junctional adenocarcinoma.
Authors: James P Dolan; Patrick J McLaren; Brian S Diggs; Paul H Schipper; Brandon H Tieu; Brett C Sheppard; Erin W Gilbert; Molly A Conroy; John G Hunter Journal: J Laparoendosc Adv Surg Tech A Date: 2017-05-09 Impact factor: 1.878
Authors: Rachel C Brierley; Daisy Gaunt; Chris Metcalfe; Jane M Blazeby; Natalie S Blencowe; Marcus Jepson; Richard G Berrisford; Kerry N L Avery; William Hollingworth; Caoimhe T Rice; Aida Moure-Fernandez; Newton Wong; Joanna Nicklin; Anni Skilton; Alex Boddy; James P Byrne; Tim Underwood; Ravi Vohra; James A Catton; Kish Pursnani; Rachel Melhado; Bilal Alkhaffaf; Richard Krysztopik; Peter Lamb; Lucy Culliford; Chris Rogers; Benjamin Howes; Katy Chalmers; Sian Cousins; Jackie Elliott; Jenny Donovan; Rachael Heys; Robin A Wickens; Paul Wilkerson; Andrew Hollowood; Christopher Streets; Dan Titcomb; Martyn Lee Humphreys; Tim Wheatley; Grant Sanders; Arun Ariyarathenam; Jamie Kelly; Fergus Noble; Graeme Couper; Richard J E Skipworth; Chris Deans; Sukhbir Ubhi; Robert Williams; David Bowrey; David Exon; Paul Turner; Vinutha Daya Shetty; Ram Chaparala; Khurshid Akhtar; Naheed Farooq; Simon L Parsons; Neil T Welch; Rebecca J Houlihan; Joanne Smith; Rachel Schranz; Nicola Rea; Jill Cooke; Alexandra Williams; Carolyn Hindmarsh; Sally Maitland; Lucy Howie; Christopher Paul Barham Journal: BMJ Open Date: 2019-11-19 Impact factor: 2.692