Literature DB >> 23987745

Detection of cellular glutathione and oxidized glutathione using magnetic-plasmonic nanocomposite-based "turn-off" surface enhanced Raman scattering.

Arindam Saha1, Nikhil R Jana.   

Abstract

Glutathione (GSH) and oxidized glutathione (GSSG) control cellular function and efficiency of anticancer therapy. Reliable detection of cellular GSH/GSSG is challenging due to their ultralow concentration (typically femtomolar concentrations) and interference by other thiol-based molecules. Here, we report a "turn-off" surface enhanced Raman scattering (SERS)-based approach for reliable detection of cellular GSH and GSSG. This approach exploits GSH-induced replacement of a Raman probe from the surface of γ-Fe2O3-Au followed by Ag growth around γ-Fe2O3-Au that generates electromagnetic hot spots at the junction between Au and Ag where the Raman probe is localized. The magnetic component of the hybrid nanoparticle concentrates the cellular GSH, and the Au/Ag-based plasmonic component provides electromagnetic hot spots for sensitive SERS. This approach is able to monitor GSH level during photothermal cancer therapy.

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Year:  2013        PMID： 23987745     DOI： 10.1021/ac4019457

Source DB:  PubMed          Journal:  Anal Chem        ISSN： 0003-2700            Impact factor:   6.986


  8 in total

1.  Detection of glutathione based on MnO2 nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter.

Authors:  Qingqing Tan; Ruirui Zhang; Rongmei Kong; Weisu Kong; Wenzhi Zhao; Fengli Qu
Journal:  Mikrochim Acta       Date:  2017-12-08       Impact factor: 5.833

2.  Sensitive fluorometric determination of glutathione using fluorescent polymer dots and the dopamine-melanin nanosystem.

Authors:  Jing Wang; Cheng Zheng; Xionghong Tan; Aixian Zheng; Yongyi Zeng; Zhenxi Zhang; Xiaolong Zhang; Xiaolong Liu
Journal:  Mikrochim Acta       Date:  2019-07-24       Impact factor: 5.833

3.  Dual sensing of glutathione and acidic pH values by using MnO2 nanosheets and 3-acetyl-7-hydroxy-2H-chromen-2-one as a fluorescent pH probe.

Authors:  Lei Fu; Yanlin Du; Zhenxi Zhang; Haiyan Sun; Aixian Zheng; Xiaolong Liu
Journal:  Mikrochim Acta       Date:  2019-07-02       Impact factor: 5.833

4.  Nitrogen-Doped Carbon Nanoparticles Derived from Silkworm Excrement as On⁻Off⁻On Fluorescent Sensors to Detect Fe(III) and Biothiols.

Authors:  Xingchang Lu; Chen Liu; Zhimin Wang; Junyi Yang; Mengjing Xu; Jun Dong; Ping Wang; Jiangjiang Gu; Feifei Cao
Journal:  Nanomaterials (Basel)       Date:  2018-06-17       Impact factor: 5.076

5.  A GSH Fluorescent Probe with a Large Stokes Shift and Its Application in Living Cells.

Authors:  Yueyuan Mao; Yediao Xu; Zhi Li; Yang Wang; Huanhuan Du; Lei Liu; Ran Ding; Guodong Liu
Journal:  Sensors (Basel)       Date:  2019-12-04       Impact factor: 3.576

6.  "Turn on" Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites.

Authors:  Thi-Hoa Le; Ji-Hyeon Kim; Sang-Joon Park
Journal:  Int J Mol Sci       Date:  2021-12-24       Impact factor: 5.923

7.  An ultrasensitive colorimetric and fluorescence dual-readout assay for glutathione with a carbon dot-MnO2 nanosheet platform based on the inner filter effect.

Authors:  Mengyuan He; Ning Shang; Bo Zheng; Gege Yue
Journal:  RSC Adv       Date:  2021-06-15       Impact factor: 4.036

8.  Synergistic Combination of Facile Thiol-Maleimide Derivatization and Supramolecular Solvent-Based Microextraction for UHPLC-HRMS Analysis of Glutathione in Biofluids.

Authors:  Mengmeng Yan; Feng Gao; Meng Chen; Qi Hu; Yuqin Yang; Kedian Chen; Penglong Wang; Haimin Lei; Qiang Ma
Journal:  Front Chem       Date:  2021-12-09       Impact factor: 5.221
  8 in total

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