Stability of Morphine-Ketamine Mixtures in 0.9% Sodium Chloride Injection Packaged in Syringes, Plastic Bags and MEDICATION CASSETTE Reservoirs.

The purpose of this study was to determine the stablilty of different intravenous mixtures of morphine and ketamine in 0.9% sodium chloride injection, USP packaged in plastic syringes, plastic bags and MEDICATION CASSETTE reservoirs (SIMS-Deltec, Inc., Minneapolis, MN). Nine morphine (1-,10-,and 25-mg/mL) and ketamine (1-,10-,and 25-mg/mL) mixtures in syringes; two morphine and ketamine mixutres (1 mg/mL and 25 mg/mL of each drug) in plastic bags: and one morpnhine and ketamine mixture (25 mg/mL of each drug) in a MEDICATION CASSETTE reservoir were investigated using a high-performance liquid chromatography analytical technique to measure drug concentrations after one to six days at room temperatue. No loss of drug was observed during the study.