Mikaël Daouphars1, Charles-Henri Hervouët2, Pierre Bohn3, Delphine Martin4, Jean Rouvet1, Florence Basuyau1, Rémi Varin2. 1. Department of Pharmacy, Cancer Centre Henri Becquerel, Rouen, France. 2. Department of Pharmacy, University Hospital Charles Nicolle, Rouen, France. 3. Nuclear Medicine Department, Cancer Centre Henri Becquerel, Rouen, France. 4. Palliative Care Unit, University Hospital Charles Nicolle, Rouen, France.
Abstract
OBJECTIVES: The study evaluated the stability of three combinations of oxycodone and ketamine diluted in normal saline (NS) after storage for 7 days at 23°C and exposed to light. METHODS: The stability of three mixtures of oxycodone and ketamine (oxycodone 0.4 mg/mL+ketamine 40 mg/mL, oxycodone 10 mg/mL+ketamine 0.1 mg/mL and oxycodone 10 mg/mL+ketamine 40 mg/mL) in NS stored in a polypropylene syringe and a polyvinyl chloride (PVC) bag was studied. The physical characteristics, including pH, colour and precipitation, were evaluated. The samples were analysed in triplicate by a stability-indicating high-performance liquid chromatography method. RESULTS: There was no significant change in the pH values of any solution. No precipitation or change in colour was observed. All formulations maintained more than 95% of the initial concentration of each drug on day 7. No trace of degradation products was detected. CONCLUSIONS: Ketamine (0.1-40 mg/mL) combined with oxycodone (0.4-10 mg/mL) is physically compatible and chemically stable for 7 days when diluted with NS, packaged in polypropylene syringe or PVC bag and stored at 23°C.
OBJECTIVES: The study evaluated the stability of three combinations of oxycodone and ketamine diluted in normal saline (NS) after storage for 7 days at 23°C and exposed to light. METHODS: The stability of three mixtures of oxycodone and ketamine (oxycodone 0.4 mg/mL+ketamine 40 mg/mL, oxycodone 10 mg/mL+ketamine 0.1 mg/mL and oxycodone 10 mg/mL+ketamine 40 mg/mL) in NS stored in a polypropylene syringe and a polyvinyl chloride (PVC) bag was studied. The physical characteristics, including pH, colour and precipitation, were evaluated. The samples were analysed in triplicate by a stability-indicating high-performance liquid chromatography method. RESULTS: There was no significant change in the pH values of any solution. No precipitation or change in colour was observed. All formulations maintained more than 95% of the initial concentration of each drug on day 7. No trace of degradation products was detected. CONCLUSIONS: Ketamine (0.1-40 mg/mL) combined with oxycodone (0.4-10 mg/mL) is physically compatible and chemically stable for 7 days when diluted with NS, packaged in polypropylene syringe or PVC bag and stored at 23°C.
Authors: Ph Hubert; J-J Nguyen-Huu; B Boulanger; E Chapuzet; P Chiap; N Cohen; P-A Compagnon; W Dewé; M Feinberg; M Lallier; M Laurentie; N Mercier; G Muzard; C Nivet; L Valat Journal: J Pharm Biomed Anal Date: 2004-11-15 Impact factor: 3.935
Authors: Ph Hubert; J-J Nguyen-Huu; B Boulanger; E Chapuzet; P Chiap; N Cohen; P-A Compagnon; W Dewé; M Feinberg; M Lallier; M Laurentie; N Mercier; G Muzard; C Nivet; L Valat; E Rozet Journal: J Pharm Biomed Anal Date: 2007-06-16 Impact factor: 3.935
Authors: Ph Hubert; J-J Nguyen-Huu; B Boulanger; E Chapuzet; N Cohen; P-A Compagnon; W Dewé; M Feinberg; M Laurentie; N Mercier; G Muzard; L Valat; E Rozet Journal: J Pharm Biomed Anal Date: 2007-07-17 Impact factor: 3.935
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