Robyn Sysko1, Michael J Devlin, Janet Schebendach, Marian Tanofsky-Kraff, Ellen Zimmerli, Judith Korner, Jack A Yanovski, Jeffrey L Zitsman, B Timothy Walsh. 1. Columbia Center for Eating Disorders, Division of Clinical Therapeutics, New York State Psychiatric Institute, New York, NY (RS, MJD, JS, EZ, BTW); the Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY (RS, MJD, JS, EZ, BTW); the Department of Medical and Clinical Psychology, Uniformed Services University of Health Sciences, Bethesda, MD (MT-K); the Section on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (MT-K and JAY); the Department of Medicine, Columbia University, New York, NY (JK); and the Center for Adolescent Bariatric Surgery, Department of Surgery, Division of Pediatric Surgery, Columbia University Medical Center, New York, NY (JLZ).
Abstract
BACKGROUND: Relatively little is known about changes in eating behavior or hormonal responses to food after bariatric surgery in adolescents. OBJECTIVE: This study compared eating behavior and hormones among adolescents in a bariatric surgery program with those in nonoverweight control adolescents and evaluated changes before and after laparoscopic adjustable gastric banding (LAGB). DESIGN: Fasting leptin, peptide YY (PYY), and ghrelin concentrations were obtained, and postprandial ghrelin and PYY area under the curve (AUC) were assessed after a single-item breakfast. Intake from an ad libitum lunchtime multi-item meal was measured. RESULTS: Compared with controls (n = 9), all presurgical candidates (n = 20) had significantly greater fasting leptin, lower fasting ghrelin, and lower AUC ghrelin but similar PYY and AUC PYY. Preoperative candidates did not differ from controls in total energy consumed during the test meal. Postoperatively, among the 11 participants with data both before and after surgery, BMI (in kg/m(2)) decreased by 3.5 (P < 0.001), significantly less energy was consumed in the test meal, and a smaller number of foods were selected. AUC ghrelin and PYY did not significantly change before or after LAGB. CONCLUSIONS: Few significant short-term changes were observed in appetitive hormones after LAGB. It is unclear whether objective measures of eating behavior will prove useful in evaluating the impact of bariatric surgery on outcomes. This trial was registered at clinicaltrials.gov as CT00764127.
BACKGROUND: Relatively little is known about changes in eating behavior or hormonal responses to food after bariatric surgery in adolescents. OBJECTIVE: This study compared eating behavior and hormones among adolescents in a bariatric surgery program with those in nonoverweight control adolescents and evaluated changes before and after laparoscopic adjustable gastric banding (LAGB). DESIGN: Fasting leptin, peptide YY (PYY), and ghrelin concentrations were obtained, and postprandial ghrelin and PYY area under the curve (AUC) were assessed after a single-item breakfast. Intake from an ad libitum lunchtime multi-item meal was measured. RESULTS: Compared with controls (n = 9), all presurgical candidates (n = 20) had significantly greater fasting leptin, lower fasting ghrelin, and lower AUC ghrelin but similar PYY and AUC PYY. Preoperative candidates did not differ from controls in total energy consumed during the test meal. Postoperatively, among the 11 participants with data both before and after surgery, BMI (in kg/m(2)) decreased by 3.5 (P < 0.001), significantly less energy was consumed in the test meal, and a smaller number of foods were selected. AUC ghrelin and PYY did not significantly change before or after LAGB. CONCLUSIONS: Few significant short-term changes were observed in appetitive hormones after LAGB. It is unclear whether objective measures of eating behavior will prove useful in evaluating the impact of bariatric surgery on outcomes. This trial was registered at clinicaltrials.gov as CT00764127.
Authors: Lauren B Shomaker; Marian Tanofsky-Kraff; Jaclyn M Zocca; Amber Courville; Merel Kozlosky; Kelli M Columbo; Laura E Wolkoff; Sheila M Brady; Melissa K Crocker; Asem H Ali; Susan Z Yanovski; Jack A Yanovski Journal: Am J Clin Nutr Date: 2010-08-18 Impact factor: 7.045
Authors: Lauren B Shomaker; Marian Tanofsky-Kraff; David M Savastano; Merel Kozlosky; Kelli M Columbo; Laura E Wolkoff; Jaclyn M Zocca; Sheila M Brady; Susan Z Yanovski; Melissa K Crocker; Asem Ali; Jack A Yanovski Journal: Am J Clin Nutr Date: 2010-05-26 Impact factor: 7.045
Authors: Robyn Sysko; Michael J Devlin; Tom B Hildebrandt; Stephanie K Brewer; Jeffrey L Zitsman; B Timothy Walsh Journal: J Clin Psychiatry Date: 2012-10 Impact factor: 4.384
Authors: Francois M H van Dielen; Jeroen Nijhuis; Sander S M Rensen; Nicolaas C Schaper; Janneke Wiebolt; Afra Koks; Fred J Prakken; Wim A Buurman; Jan Willem M Greve Journal: Surg Obes Relat Dis Date: 2009-12-11 Impact factor: 4.734
Authors: Janet E Schebendach; Laurel Es Mayer; Michael J Devlin; Evelyn Attia; Isobel R Contento; Randi L Wolf; B Timothy Walsh Journal: Am J Clin Nutr Date: 2008-04 Impact factor: 7.045