| Literature DB >> 23985735 |
Justin Jee1, Andrew Sundstrom, Steven E Massey, Bud Mishra.
Abstract
This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.Keywords: RNA world; genetic code; information-asymmetric games; signalling
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Year: 2013 PMID: 23985735 PMCID: PMC3785830 DOI: 10.1098/rsif.2013.0614
Source DB: PubMed Journal: J R Soc Interface ISSN: 1742-5662 Impact factor: 4.118