Literature DB >> 23985735

What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?

Justin Jee1, Andrew Sundstrom, Steven E Massey, Bud Mishra.   

Abstract

This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.

Keywords:  RNA world; genetic code; information-asymmetric games; signalling

Mesh:

Substances:

Year:  2013        PMID: 23985735      PMCID: PMC3785830          DOI: 10.1098/rsif.2013.0614

Source DB:  PubMed          Journal:  J R Soc Interface        ISSN: 1742-5662            Impact factor:   4.118


  33 in total

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  6 in total

1.  Genetic Code Error Minimization as a Non-Adaptive But Beneficial Trait.

Authors:  Steven E Massey
Journal:  J Mol Evol       Date:  2019-01-02       Impact factor: 2.395

2.  Origin of biomolecular games: deception and molecular evolution.

Authors:  Steven E Massey; Bud Mishra
Journal:  J R Soc Interface       Date:  2018-09       Impact factor: 4.118

3.  How signalling games explain mimicry at many levels: from viral epidemiology to human sociology.

Authors:  William Casey; Steven E Massey; Bud Mishra
Journal:  J R Soc Interface       Date:  2021-02-24       Impact factor: 4.118

4.  Genetic code evolution reveals the neutral emergence of mutational robustness, and information as an evolutionary constraint.

Authors:  Steven E Massey
Journal:  Life (Basel)       Date:  2015-04-24

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Authors:  Gustavo Caetano-Anollés; Feng-Jie Sun
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6.  How Signaling Games Explain Mimicry at Many Levels: From Viral Epidemiology to Human Sociology.

Authors:  William Casey; Steven E Massey; Bud Mishra
Journal:  Res Sq       Date:  2020-08-06
  6 in total

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