Chelsea Cooper1, Jeffrey D Wayne2, Elizabeth M Damstetter1, Mary Martini1, Jennifer Gordon3, Joan Guitart1, Dennis P West1, Beatrice Nardone1, Alfred Rademaker4, Pedram Gerami5. 1. Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 2. Department of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 3. Department of Dermatology, University of Texas Southwestern-Austin, Austin, Texas. 4. Department of Preventive Medicine, Northwestern University, Chicago, Illinois. 5. Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois. Electronic address: Pedram.Gerami@nmff.org.
Abstract
BACKGROUND: The 2009 American Joint Committee on Cancer criteria for thin cutaneous melanomas recommend staging sentinel lymph node (SLN) biopsy (SLNB) for select stage IB tumors. SLNB in this population remains controversial because of low rates of node positivity and inconsistent prognostic parameters. OBJECTIVE: The purpose of this study was to examine the association between multiple clinicopathologic features and SLNB result, and clinical outcome. METHODS: Clinical and pathologic parameters from patients with melanomas less than or equal to 1.00 mm receiving wide local excision with SLNB at our institution from 2001 through 2010 were recorded. Analysis for any statistically significant relationships between recorded parameters and SLN results and outcome were performed. RESULTS: A total of 189 cases yielded 3 positive SLNBs (1.6%). Disease progression occurred in 6 cases (3.2%). Positive SLNB predicted distant metastasis and death from disease (P = .0017). Mitotic rate was not associated with a positive SLNB result. LIMITATIONS: The follow-up time for this study was limited (mean = 40.7 months). CONCLUSION: Our data confirm a statistically significant relationship between SLNB result and likelihood for distant metastasis in thin melanoma. There was a trend for a relationship between mitotic rate and clinical outcome. This relationship reached statistical significance at a mitotic rate of greater than 3 mitoses/mm(2).
BACKGROUND: The 2009 American Joint Committee on Cancer criteria for thin cutaneous melanomas recommend staging sentinel lymph node (SLN) biopsy (SLNB) for select stage IB tumors. SLNB in this population remains controversial because of low rates of node positivity and inconsistent prognostic parameters. OBJECTIVE: The purpose of this study was to examine the association between multiple clinicopathologic features and SLNB result, and clinical outcome. METHODS: Clinical and pathologic parameters from patients with melanomas less than or equal to 1.00 mm receiving wide local excision with SLNB at our institution from 2001 through 2010 were recorded. Analysis for any statistically significant relationships between recorded parameters and SLN results and outcome were performed. RESULTS: A total of 189 cases yielded 3 positive SLNBs (1.6%). Disease progression occurred in 6 cases (3.2%). Positive SLNB predicted distant metastasis and death from disease (P = .0017). Mitotic rate was not associated with a positive SLNB result. LIMITATIONS: The follow-up time for this study was limited (mean = 40.7 months). CONCLUSION: Our data confirm a statistically significant relationship between SLNB result and likelihood for distant metastasis in thin melanoma. There was a trend for a relationship between mitotic rate and clinical outcome. This relationship reached statistical significance at a mitotic rate of greater than 3 mitoses/mm(2).
Authors: Antonio Tejera-Vaquerizo; Simone Ribero; Susana Puig; Aram Boada; Sabela Paradela; David Moreno-Ramírez; Javier Cañueto; Blanca de Unamuno; Ana Brinca; Miguel A Descalzo-Gallego; Simona Osella-Abate; Paola Cassoni; Cristina Carrera; Sergi Vidal-Sicart; Antoni Bennássar; Ramón Rull; Llucìa Alos; Celia Requena; Isidro Bolumar; Víctor Traves; Ángel Pla; A Fernández-Orland; Ane Jaka; María T Fernández-Figueres; Josep M Hilari; Pol Giménez-Xavier; Ricardo Vieira; Rafael Botella-Estrada; Concepción Román-Curto; Lara Ferrándiz; Nicolás Iglesias-Pena; Carlos Ferrándiz; Josep Malvehy; Pietro Quaglino; Eduardo Nagore Journal: Cancer Med Date: 2019-06-18 Impact factor: 4.452
Authors: A Kocsis; L Karsko; Zs Kurgyis; Zs Besenyi; L Pavics; E Dosa-Racz; E Kis; E Baltas; H Ocsai; E Varga; B Bende; A Varga; G Mohos; I Korom; J Varga; L Kemeny; I B Nemeth; J Olah Journal: Pathol Oncol Res Date: 2019-12-02 Impact factor: 3.201