OBJECTIVE: Using objective laboratory and clinical criteria to more accurately determine the 99th percentile values for cardiac troponin I and T. DESIGN AND METHODS: We measured cardiac troponin T and cardiac troponin I with high-sensitivity assays in a large cohort of apparently healthy community subjects and calculated 99th percentiles for different sexes and ages. Subjects with possible subclinical disease were eliminated based on objective laboratory criteria, eGFR and NT-proBNP, and clinical criteria, history and examination and echocardiogram. RESULTS: For men and women of all ages, separately, more than 50% of subjects were excluded using these criteria, with a lesser proportion of younger subjects being excluded. In men aged <75 years, the 99th percentile for cTnI decreased by more than 50% from 22.9 ng/L to 10.3 ng/L. In other age groups and for cTnT the decrease was smaller (%) but still considerable. CONCLUSIONS: For establishing cardiac troponin 99th percentiles, simply using self-reporting of health is insufficient. Objective laboratory measures and clinical and echocardiographic assessments are essential to define a healthy population, especially in older persons.
OBJECTIVE: Using objective laboratory and clinical criteria to more accurately determine the 99th percentile values for cardiac troponin I and T. DESIGN AND METHODS: We measured cardiac troponin T and cardiac troponin I with high-sensitivity assays in a large cohort of apparently healthy community subjects and calculated 99th percentiles for different sexes and ages. Subjects with possible subclinical disease were eliminated based on objective laboratory criteria, eGFR and NT-proBNP, and clinical criteria, history and examination and echocardiogram. RESULTS: For men and women of all ages, separately, more than 50% of subjects were excluded using these criteria, with a lesser proportion of younger subjects being excluded. In men aged <75 years, the 99th percentile for cTnI decreased by more than 50% from 22.9 ng/L to 10.3 ng/L. In other age groups and for cTnT the decrease was smaller (%) but still considerable. CONCLUSIONS: For establishing cardiac troponin 99th percentiles, simply using self-reporting of health is insufficient. Objective laboratory measures and clinical and echocardiographic assessments are essential to define a healthy population, especially in older persons.
Authors: Matthew T H Lowry; Dimitrios Doudesis; Ryan Wereski; Dorien M Kimenai; Christopher Tuck; Amy V Ferry; Anda Bularga; Caelan Taggart; Kuan K Lee; Andrew R Chapman; Anoop S V Shah; David E Newby; Nicholas L Mills; Atul Anand Journal: Circulation Date: 2022-09-15 Impact factor: 39.918
Authors: Karin Wildi; Maria Rubini Gimenez; Raphael Twerenbold; Tobias Reichlin; Cedric Jaeger; Amely Heinzelmann; Christiane Arnold; Berit Nelles; Sophie Druey; Philip Haaf; Petra Hillinger; Nicolas Schaerli; Philipp Kreutzinger; Yunus Tanglay; Thomas Herrmann; Zoraida Moreno Weidmann; Lian Krivoshei; Michael Freese; Claudia Stelzig; Christian Puelacher; Katharina Rentsch; Stefan Osswald; Christian Mueller Journal: Circulation Date: 2015-05-06 Impact factor: 29.690
Authors: Rodrigo Fernández-Jiménez; Jacobo Silva; Sara Martínez-Martínez; M Dolores López-Maderuelo; Mario Nuno-Ayala; José Manuel García-Ruiz; Ana García-Álvarez; Leticia Fernández-Friera; Tech Gonzalo Pizarro; Jaime García-Prieto; David Sanz-Rosa; Gonzalo López-Martin; Antonio Fernández-Ortiz; Carlos Macaya; Valentin Fuster; Juan Miguel Redondo; Borja Ibanez Journal: J Am Heart Assoc Date: 2015-01-21 Impact factor: 5.501
Authors: João Pedro Ferreira; Mário Santos; Sofia Almeida; Irene Marques; Paulo Bettencourt; Henrique Carvalho Journal: Cardiol Res Pract Date: 2014-08-28 Impact factor: 1.866