Literature DB >> 23973371

Nek8 couples renal ciliopathies to DNA damage and checkpoint control.

Peter K Jackson1.   

Abstract

In this issue, Choi et al. (2013) discover a molecular link between the Nek8 kinase, mutated in the renal ciliopathy nephronophthisis, and DNA damage control by cyclin A/Cdk2 and ATR-Chk1, providing new ideas for targeted therapies limiting tissue degeneration.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23973371     DOI： 10.1016/j.molcel.2013.08.013

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  14 in total

1.  A LARGe surprise links ATR and Rho.

Authors:  Alexandre Maréchal; Lee Zou
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

2.  The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells.

Authors:  Xiao-Fei Ding; Jun Zhou; Qiong-Ying Hu; Shuang-Chun Liu; Guang Chen
Journal:  J Biol Chem       Date:  2014-12-01       Impact factor: 5.157

3.  C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.

Authors:  John Yochem; Vladimir Lažetić; Leslie Bell; Lihsia Chen; David Fay
Journal:  Dev Biol       Date:  2014-12-16       Impact factor: 3.582

4.  Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats.

Authors:  Michelle H T Ta; Kristina G Schwensen; David Liuwantara; David L Huso; Terry Watnick; Gopala K Rangan
Journal:  World J Nephrol       Date:  2016-07-06

Review 5.  DNA damage response in cisplatin-induced nephrotoxicity.

Authors:  Shiyao Zhu; Navjotsingh Pabla; Chengyuan Tang; Liyu He; Zheng Dong
Journal:  Arch Toxicol       Date:  2015-11-13       Impact factor: 5.153

6.  The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans.

Authors:  Simon R F Warburton-Pitt; Malan Silva; Ken C Q Nguyen; David H Hall; Maureen M Barr
Journal:  PLoS Genet       Date:  2014-12-11       Impact factor: 5.917

Review 7.  Mitotic Regulation by NEK Kinase Networks.

Authors:  Andrew M Fry; Richard Bayliss; Joan Roig
Journal:  Front Cell Dev Biol       Date:  2017-12-01

8.  Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.

Authors:  Kade M Power; Jyothi S Akella; Amanda Gu; Jonathon D Walsh; Sebastian Bellotti; Margaret Morash; Winnie Zhang; Yasmin H Ramadan; Nicole Ross; Andy Golden; Harold E Smith; Maureen M Barr; Robert O'Hagan
Journal:  PLoS Genet       Date:  2020-10-16       Impact factor: 5.917

Review 9.  RPGR: Its role in photoreceptor physiology, human disease, and future therapies.

Authors:  Roly D Megaw; Dinesh C Soares; Alan F Wright
Journal:  Exp Eye Res       Date:  2015-06-17       Impact factor: 3.467

10.  Never-in-mitosis A-related kinase 8, a novel target of von-Hippel-Lindau tumor suppressor protein, promotes gastric cancer cell proliferation.

Authors:  Xiao-Fei Ding; Jie Chen; Jun Zhou; Guang Chen; Ying-Liang Wu
Journal:  Oncol Lett       Date:  2018-08-20       Impact factor: 2.967
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