Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A Central role for mTOR in lipid homeostasis.

Literature DB >> 23973332

A Central role for mTOR in lipid homeostasis.

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23973332 PMCID： PMC3818790 DOI： 10.1016/j.cmet.2013.08.002

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

25 in total

1. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

Authors: Asami Hagiwara; Marion Cornu; Nadine Cybulski; Pazit Polak; Charles Betz; Francesca Trapani; Luigi Terracciano; Markus H Heim; Markus A Rüegg; Michael N Hall
Journal: Cell Metab Date: 2012-04-19 Impact factor: 27.287

2. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

Authors: Jessica L Yecies; Hui H Zhang; Suchithra Menon; Sihao Liu; Derek Yecies; Alex I Lipovsky; Cem Gorgun; David J Kwiatkowski; Gökhan S Hotamisligil; Chih-Hao Lee; Brendan D Manning
Journal: Cell Metab Date: 2011-07-06 Impact factor: 27.287

3. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver.

Authors: Kyeongjin Kim; Suhkneung Pyo; Sung Hee Um
Journal: Hepatology Date: 2012-03-08 Impact factor: 17.425

4. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

Authors: Shomit Sengupta; Timothy R Peterson; Mathieu Laplante; Stephanie Oh; David M Sabatini
Journal: Nature Date: 2010-12-23 Impact factor: 49.962

5. S6K1 plays a critical role in early adipocyte differentiation.

Authors: Larissa S Carnevalli; Kouhei Masuda; Francesca Frigerio; Olivier Le Bacquer; Sung Hee Um; Valentina Gandin; Ivan Topisirovic; Nahum Sonenberg; George Thomas; Sara C Kozma
Journal: Dev Cell Date: 2010-05-18 Impact factor: 12.270

6. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.

Authors: C Florian Bentzinger; Klaas Romanino; Dimitri Cloëtta; Shuo Lin; Joseph B Mascarenhas; Filippo Oliveri; Jinyu Xia; Emilio Casanova; Céline F Costa; Marijke Brink; Francesco Zorzato; Michael N Hall; Markus A Rüegg
Journal: Cell Metab Date: 2008-11 Impact factor: 27.287

7. mTOR complex 2 in adipose tissue negatively controls whole-body growth.

Authors: Nadine Cybulski; Pazit Polak; Johan Auwerx; Markus A Rüegg; Michael N Hall
Journal: Proc Natl Acad Sci U S A Date: 2009-06-03 Impact factor: 11.205

8. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.

Authors: Joshua L Owen; Yuanyuan Zhang; Soo-Han Bae; Midhat S Farooqi; Guosheng Liang; Robert E Hammer; Joseph L Goldstein; Michael S Brown
Journal: Proc Natl Acad Sci U S A Date: 2012-08-27 Impact factor: 11.205

9. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

Authors: Kevin T Jones; Elisabeth R Greer; David Pearce; Kaveh Ashrafi
Journal: PLoS Biol Date: 2009-03-03 Impact factor: 8.029

10. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

Authors: Thomas Porstmann; Claudio R Santos; Beatrice Griffiths; Megan Cully; Mary Wu; Sally Leevers; John R Griffiths; Yuen-Li Chung; Almut Schulze
Journal: Cell Metab Date: 2008-09 Impact factor: 27.287

153 in total

Review 1. White Adipose Tissue Browning: A Double-edged Sword.

Authors: Abdikarim Abdullahi; Marc G Jeschke
Journal: Trends Endocrinol Metab Date: 2016-07-05 Impact factor: 12.015

2. mTORC2 in the center of cancer metabolic reprogramming.

Authors: Kenta Masui; Webster K Cavenee; Paul S Mischel
Journal: Trends Endocrinol Metab Date: 2014-05-21 Impact factor: 12.015

3. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.

Authors: Richard D Semba; Indi Trehan; Marta Gonzalez-Freire; Klaus Kraemer; Ruin Moaddel; M Isabel Ordiz; Luigi Ferrucci; Mark J Manary
Journal: Adv Nutr Date: 2016-09-15 Impact factor: 8.701

A Central role for mTOR in lipid homeostasis.

1. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

2. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.

3. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver.

4. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

5. S6K1 plays a critical role in early adipocyte differentiation.

6. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.

7. mTOR complex 2 in adipose tissue negatively controls whole-body growth.

8. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase.

9. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

10. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

Review 1. White Adipose Tissue Browning: A Double-edged Sword.

2. mTORC2 in the center of cancer metabolic reprogramming.

3. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.

4. Feedback regulation of mTORC1 by Grb10 in metabolism and beyond.

5. Egr1 mediates the effect of insulin on leptin transcription in adipocytes.

6. 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL.

Review 7. Making new contacts: the mTOR network in metabolism and signalling crosstalk.

8. mTOR signaling and transcriptional regulation in T lymphocytes.

9. Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.

Review 10. Multiple amino acid sensing inputs to mTORC1.