Literature DB >> 23966405

Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells.

Steven C Hatch1, Luca Sardo, Jianbo Chen, Ryan Burdick, Robert Gorelick, Matthew J Fivash, Vinay K Pathak, Wei-Shau Hu.   

Abstract

The enrichment of HIV-1 macromolecules at the uropod of polarized T cells can significantly promote virus assembly and cell-mediated infection. Using live-cell fluorescence microscopy, we demonstrate that full-length HIV-1 RNA is enriched at the uropod membrane; furthermore, the presence of HIV-1 Gag containing a functional nucleocapsid domain is necessary for this HIV-1 RNA enrichment. The results from these studies provide novel insights into the mechanism of HIV-1 replication in polarized T cells.

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Year:  2013        PMID： 23966405      PMCID： PMC3807364          DOI： 10.1128/JVI.01680-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

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Journal:  Science       Date:  2002-05-16       Impact factor: 47.728

2.  Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts.

Authors:  Lisa A Mingle; Nataly N Okuhama; Jian Shi; Robert H Singer; John Condeelis; Gang Liu
Journal:  J Cell Sci       Date:  2005-06-01       Impact factor: 5.285

3.  Transcriptional antitermination in the bgl operon of E. coli is modulated by a specific RNA binding protein.

Authors:  F Houman; M R Diaz-Torres; A Wright
Journal:  Cell       Date:  1990-09-21       Impact factor: 41.582

Review 4.  Bringing up the rear: defining the roles of the uropod.

Authors:  Francisco Sánchez-Madrid; Juan M Serrador
Journal:  Nat Rev Mol Cell Biol       Date:  2009-04-17       Impact factor: 94.444

5.  Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a late assembly domain.

Authors:  M A Accola; B Strack; H G Göttlinger
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

Review 6.  How and why does beta-actin mRNA target?

Authors:  John Condeelis; Robert H Singer
Journal:  Biol Cell       Date:  2005-01       Impact factor: 4.458

7.  Assembly properties of human immunodeficiency virus type 1 Gag-leucine zipper chimeras: implications for retrovirus assembly.

Authors:  Rachael M Crist; Siddhartha A K Datta; Andrew G Stephen; Ferri Soheilian; Jane Mirro; Robert J Fisher; Kunio Nagashima; Alan Rein
Journal:  J Virol       Date:  2008-12-10       Impact factor: 5.103

8.  Analysis of the initiating events in HIV-1 particle assembly and genome packaging.

Authors:  Sebla B Kutluay; Paul D Bieniasz
Journal:  PLoS Pathog       Date:  2010-11-18       Impact factor: 6.823

9.  beta-Actin messenger RNA localization and protein synthesis augment cell motility.

Authors:  E H Kislauskis; X Zhu; R H Singer
Journal:  J Cell Biol       Date:  1997-03-24       Impact factor: 10.539

10.  HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse.

Authors:  Clare Jolly; Kirk Kashefi; Michael Hollinshead; Quentin J Sattentau
Journal:  J Exp Med       Date:  2004-01-19       Impact factor: 14.307
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  4 in total

1.  HIV-1 Exploits Transitions Between CD4+ T Cell Migration and Activation.

Authors:  Robert L Furler; Douglas F Nixon
Journal:  AIDS Res Hum Retroviruses       Date:  2021-11-19       Impact factor: 2.205

2.  A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection.

Authors:  Scott P Lawrence; Samra E Elser; Workineh Torben; Robert V Blair; Bapi Pahar; Pyone P Aye; Faith Schiro; Dawn Szeltner; Lara A Doyle-Meyers; Beth S Haggarty; Andrea P O Jordan; Josephine Romano; George J Leslie; Xavier Alvarez; David H O'Connor; Roger W Wiseman; Christine M Fennessey; Yuan Li; Michael Piatak; Jeffrey D Lifson; Celia C LaBranche; Andrew A Lackner; Brandon F Keele; Nicholas J Maness; Mark Marsh; James A Hoxie
Journal:  PLoS Pathog       Date:  2022-06-17       Impact factor: 7.464

3.  Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes.

Authors:  Fei Li; Xaver Sewald; Jing Jin; Nathan M Sherer; Walther Mothes
Journal:  J Virol       Date:  2014-06-25       Impact factor: 5.103

Review 4.  Role of Gag and lipids during HIV-1 assembly in CD4(+) T cells and macrophages.

Authors:  Charlotte Mariani; Marion Desdouits; Cyril Favard; Philippe Benaroch; Delphine M Muriaux
Journal:  Front Microbiol       Date:  2014-06-25       Impact factor: 5.640
  4 in total

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