Literature DB >> 23964018

Does the cerebellum initiate movement?

W T Thach1.   

Abstract

Opinion is divided on what the exact function of the cerebellum is. Experiments are summarized that support the following views: (1) the cerebellum is a combiner of multiple movement factors; (2) it contains anatomically fixed permanent focal representation of individual body parts (muscles and segments) and movement modes (e.g., vestibular driven vs. cognitive driven); (3) it contains flexible changing representations/memory of physical properties of the body parts including muscle strength, segment inertia, joint viscosity, and segmental interaction torques (dynamics); (4) it contains mechanisms for learning and storage of the properties in item no. 3 through trial-and-error practice; (5) it provides for linkage of body parts, motor modes, and motordynamics via the parallel fiber system; (6) it combines and integrates the many factors so as to initiate coordinated movements of the many body parts; (7) it is thus enabled to play the unique role of initiating coordinated movements; and (8) this unique causative role is evidenced by the fact that: (a) electrical stimulation of the cerebellum can initiate compound coordinated movements; (b) in naturally initiated compound movements, cerebellar discharge precedes that in downstream target structures such as motor cerebral cortex; and (c) cerebellar ablation abolishes the natural production of compound movements in the awake alert individuals.

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Year:  2014        PMID: 23964018     DOI: 10.1007/s12311-013-0506-7

Source DB:  PubMed          Journal:  Cerebellum        ISSN: 1473-4222            Impact factor:   3.847


  34 in total

1.  Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movement.

Authors:  W T Thach
Journal:  Brain Res       Date:  1975-05-02       Impact factor: 3.252

2.  Cerebellar control of constrained and unconstrained movements. I. Nuclear inactivation.

Authors:  H P Goodkin; W T Thach
Journal:  J Neurophysiol       Date:  2003-02       Impact factor: 2.714

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Authors:  P F Gilbert; W T Thach
Journal:  Brain Res       Date:  1977-06-10       Impact factor: 3.252

4.  Time and frequency characteristics of Purkinje cell complex spikes in the awake monkey performing a nonperiodic task.

Authors:  Shahin Hakimian; Scott A Norris; Bradley Greger; Jeffrey G Keating; Charles H Anderson; W Thomas Thach
Journal:  J Neurophysiol       Date:  2008-05-21       Impact factor: 2.714

5.  Nonclock behavior of inferior olive neurons: interspike interval of Purkinje cell complex spike discharge in the awake behaving monkey is random.

Authors:  J G Keating; W T Thach
Journal:  J Neurophysiol       Date:  1995-04       Impact factor: 2.714

6.  Internal models in the cerebellum.

Authors:  D M Wolpert; R C Miall; M Kawato
Journal:  Trends Cogn Sci       Date:  1998-09-01       Impact factor: 20.229

7.  Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells.

Authors:  M Ito; M Sakurai; P Tongroach
Journal:  J Physiol       Date:  1982-03       Impact factor: 5.182

8.  Somatosensory receptive fields of single units in cat cerebellar cortex.

Authors:  W T Thach
Journal:  J Neurophysiol       Date:  1967-07       Impact factor: 2.714

9.  Throwing while looking through prisms. I. Focal olivocerebellar lesions impair adaptation.

Authors:  T A Martin; J G Keating; H P Goodkin; A J Bastian; W T Thach
Journal:  Brain       Date:  1996-08       Impact factor: 13.501

10.  Anatomical evidence for segregated focal groupings of efferent cells and their terminal ramifications in the cerebellothalamic pathway of the monkey.

Authors:  C Asanuma; W R Thach; E G Jones
Journal:  Brain Res       Date:  1983-05       Impact factor: 3.252

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Journal:  J Comp Neurol       Date:  2015-06-10       Impact factor: 3.215

2.  Intersegmental coordination patterns are differently affected in Parkinson's disease and cerebellar ataxia.

Authors:  Simon D Israeli-Korn; Avi Barliya; Caroline Paquette; Erika Franzén; Rivka Inzelberg; Fay B Horak; Tamar Flash
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4.  Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity.

Authors:  Sommer L Amundsen Huffmaster; Gustaf M Van Acker; Carl W Luchies; Paul D Cheney
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Review 5.  The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior: A Clinical Perspective.

Authors:  Michael S Salman; Peter Tsai
Journal:  Neuroimaging Clin N Am       Date:  2016-08       Impact factor: 2.264

Review 6.  Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies.

Authors:  Hiroshi Mitoma; Mario Manto
Journal:  Cerebellum       Date:  2022-01-22       Impact factor: 3.847

Review 7.  Major remaining gaps in models of sensorimotor systems.

Authors:  Gerald E Loeb; George A Tsianos
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Review 8.  Bayesian action&perception: representing the world in the brain.

Authors:  Gerald E Loeb; Jeremy A Fishel
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9.  Impaired Adaptive Motor Learning Is Correlated With Cerebellar Hemispheric Gray Matter Atrophy in Spinocerebellar Ataxia Patients: A Voxel-Based Morphometry Study.

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10.  In vivo cerebellar circuit function is disrupted in an mdx mouse model of Duchenne muscular dystrophy.

Authors:  Trace L Stay; Lauren N Miterko; Marife Arancillo; Tao Lin; Roy V Sillitoe
Journal:  Dis Model Mech       Date:  2019-12-09       Impact factor: 5.758

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