Literature DB >> 23962161

Rubrolide R: a new furanone metabolite from the ascidian Synoicum of the Indian Ocean.

Desaraju Smitha1, Muthyala Murali Krishna Kumar, Hechhu Ramana, Desaraju Venkata Rao.   

Abstract

A new furanone metabolite of the rubrolide family, rubrolide R as diacetate (1), was isolated from a new species of the ascidian Synoicum, besides the known compounds rubrolide A (as diacetate), cadiolide B and prunolide A. The structure of the new rubrolide was elucidated by a study of spectral data. The crude extract and isolated compounds (prunolide A and cadiolide B) showed antiviral activity against the Japanese encephalitis virus. Prunolide A showed cytotoxic activity against breast cancer cell lines at a concentration of < 1 μM.

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Year:  2013        PMID： 23962161     DOI： 10.1080/14786419.2013.827194

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  6 in total

1.  Molecular Insight into Gene Response of Diorcinol- and Rubrolide-Treated Biofilms of the Emerging Pathogen Stenotrophomonas maltophilia.

Authors:  Mirja Gudzuhn; Ifey Alio; Raphael Moll; Jessica de Vries; Jacob Boehlich; Maik Assmann; Jasmin Janneschütz; Nina Schützenmeister; Axel Himmelbach; Anja Poehlein; Rolf Daniel; Wolfgang R Streit
Journal:  Microbiol Spectr       Date:  2022-04-26

Review 2.  Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Authors:  Gordon W Gribble
Journal:  Mar Drugs       Date:  2015-06-30       Impact factor: 5.118

Review 3.  Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

Authors:  Satheesh Kumar Palanisamy; N M Rajendran; Angela Marino
Journal:  Nat Prod Bioprospect       Date:  2017-01-17

4.  Targeted Isolation of Rubrolides from the New Zealand Marine Tunicate Synoicum kuranui.

Authors:  Joe Bracegirdle; Luke J Stevenson; Michael J Page; Jeremy G Owen; Robert A Keyzers
Journal:  Mar Drugs       Date:  2020-06-27       Impact factor: 5.118

5.  Chlorinated metabolites with antibacterial activities from a deep-sea-derived Spiromastix fungus.

Authors:  Siwen Niu; Dong Liu; Zongze Shao; Jiang Huang; Aili Fan; Wenhan Lin
Journal:  RSC Adv       Date:  2021-09-03       Impact factor: 4.036

6.  Halogenation-Guided Chemical Screening Provides Insight into Tjipanazole Biosynthesis by the Cyanobacterium Fischerella ambigua.

Authors:  Tomasz Chilczuk; Till F Schäberle; Sahel Vahdati; Ute Mettal; Mustafa El Omari; Heike Enke; Michael Wiese; Gabriele M König; Timo H J Niedermeyer
Journal:  Chembiochem       Date:  2020-04-16       Impact factor: 3.164
  6 in total

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