| Literature DB >> 23960847 |
Abstract
On account of the reported anticancer of pyrimidine and condensed pyrimidine, a new pyrimido [3,2-b]-1,2,4,5-tetrazine 3a , b , 5c , d , 6, 9, pyrimido [3,2-b]-1,2,4-triazine 10, 11, pyrimido [3,2-b]-1,2,4-triazole 12 and pyrimidine derivatives 1,2a , b , 4c , d , 8, 13, 14, 15 and 16 were synthesized through different chemical reactions. Structures of all synthesized compounds were supported by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against human liver cancer cell line (HEPG2).Entities:
Keywords: Anticancer; Pyrimidine derivatives; Pyrimido[3,2-b]-1,2,4,5-tetrazine; Pyrimido[3,2-b]-1,2,4-triazole; Pyrimido[3,2-b]1,2,4-triazine
Year: 2012 PMID： 23960847 PMCID： PMC3745201 DOI： 10.1016/j.jsps.2012.09.002
Source DB: PubMed Journal: Saudi Pharm J ISSN： 1319-0164 Impact factor: 4.330