Literature DB >> 14505653

Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties.

Martin J Di Grandi1, Kevin J Curran, Ellen Z Baum, Geraldine Bebernitz, George A Ellestad, Wei-Dong Ding, Stanley A Lang, Miriam Rossi, Jonathan D Bloom.   

Abstract

The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.

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Year:  2003        PMID： 14505653     DOI： 10.1016/s0960-894x(03)00789-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and anticancer activity of some fused pyrimidines and related heterocycles.

Authors:  S A Al-Issa
Journal:  Saudi Pharm J       Date:  2012-10-24       Impact factor: 4.330

Review 2.  Protease inhibitors and their peptidomimetic derivatives as potential drugs.

Authors:  Georgie Fear; Slavko Komarnytsky; Ilya Raskin
Journal:  Pharmacol Ther       Date:  2006-09-22       Impact factor: 12.310

3.  Reaction of nitrilimines with 2-substituted aza-heterocycles. Synthesis of pyrrolo[1,2-a]pyridine and pyrimido[2,1-d]1,2,3,5- tetrazine.

Authors:  Adel M Awadallah; Jalal A Zahra
Journal:  Molecules       Date:  2008-01-28       Impact factor: 4.411
  3 in total

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