| Literature DB >> 23960788 |
Rahul G S Maheshwari1, Rakesh K Tekade, Piyoosh A Sharma, Gajanan Darwhekar, Abhishek Tyagi, Rakesh P Patel, Dinesh K Jain.
Abstract
THE OBJECTIVE OF WORK WAS TO FORMULATE, EVALUATE AND COMPARE THE TRANSDERMAL POTENTIAL OF NOVEL VESICULAR NANOCARRIERS: ethosomes and ultradeformable liposomes, containing clotrimazole (CLT), an anti-fungal bioactive. The ethosomal formulation (ET4) and ultradeformable liposomal (UL) formulation (TT3) showed highest entrapment 68.73 ± 1.4% and 55.51 ± 1.7%, optimal nanometric size range 132 ± 9.5 nm and 121 ± 9.7 nm, and smallest polydispersity index 0.027 ± 0.011 and 0.067 ± 0.009, respectively. The formulation ET4 provided enhanced transdermal flux 56.25 ± 5.49 μg/cm(2)/h and decreased the lag time of 0.9 h in comparison to TT3 formulation (50.16 ± 3.84 μg/cm(2)/h; 1.0 h). Skin interaction and FT-IR studies revealed greater penetration enhancing effect of ET4 than TT3 formulation. ET4 formulation also had the highest zone of inhibition (34.6 ± 0.57 mm), in contrast to TT3 formulation (29.6 ± 0.57 mm) and marketed cream formulation (19.0 ± 1.00 mm) against candidal species. Results suggested ethosomes to be the most proficient carrier system for dermal and transdermal delivery of clotrimazole.Entities:
Keywords: Anticandidal efficiency; Atomic force microscopy; Ethosomes; Nanocarriers; Ultradeformable liposomes
Year: 2011 PMID： 23960788 PMCID： PMC3744933 DOI： 10.1016/j.jsps.2011.10.001
Source DB: PubMed Journal: Saudi Pharm J ISSN： 1319-0164 Impact factor: 4.330