OBJECTIVE: Chronic lung disease is exacerbated by comorbid psychiatric issues and treatment of depression may improve disease symptoms. We sought to add to the literature as to whether depression is associated with pulmonary function in healthy adults. METHODS: In 2551 healthy adults from New York State, we studied the association of depression via the Center for Epidemiologic Studies Depression scale (CES-D) scale score and forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) using general linear models and a cross-sectional design. RESULTS: We identified statistically significant inverse trends in FEV1, FVC, FEV1%, and FVC% by CES-D category, especially in ever-smokers and men. When adjusted for covariates, the difference in FEV1 and FEV1% for smokers with more than 18.5 lifetime pack-years from CES-D scores 0 to 3 to 16 or more (depressed) is approximately 0.25 l and 5.0% (adjusted p values for trend are <.001 and .019, respectively). In men, we also observed statistically significant inverse trends in pulmonary function with increasing CES-D. CONCLUSIONS: We identified an inverse association of depressive symptoms and pulmonary function in healthy adults, especially in men and individuals with a heavy smoking history. Further studies of these associations are essential for the development and tailoring of interventions for the prevention and treatment of chronic lung disease.
OBJECTIVE:Chronic lung disease is exacerbated by comorbid psychiatric issues and treatment of depression may improve disease symptoms. We sought to add to the literature as to whether depression is associated with pulmonary function in healthy adults. METHODS: In 2551 healthy adults from New York State, we studied the association of depression via the Center for Epidemiologic Studies Depression scale (CES-D) scale score and forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) using general linear models and a cross-sectional design. RESULTS: We identified statistically significant inverse trends in FEV1, FVC, FEV1%, and FVC% by CES-D category, especially in ever-smokers and men. When adjusted for covariates, the difference in FEV1 and FEV1% for smokers with more than 18.5 lifetime pack-years from CES-D scores 0 to 3 to 16 or more (depressed) is approximately 0.25 l and 5.0% (adjusted p values for trend are <.001 and .019, respectively). In men, we also observed statistically significant inverse trends in pulmonary function with increasing CES-D. CONCLUSIONS: We identified an inverse association of depressive symptoms and pulmonary function in healthy adults, especially in men and individuals with a heavy smoking history. Further studies of these associations are essential for the development and tailoring of interventions for the prevention and treatment of chronic lung disease.
Entities:
Keywords:
chronic lung disease; depression; pulmonary disease; respiratory function tests
Authors: H J Schünemann; P Muti; J L Freudenheim; D Armstrong; R Browne; R A Klocke; M Trevisan Journal: Am J Epidemiol Date: 1997-12-01 Impact factor: 4.897
Authors: H J Schünemann; B J Grant; J L Freudenheim; P Muti; R W Browne; J A Drake; R A Klocke; M Trevisan Journal: Am J Respir Crit Care Med Date: 2001-04 Impact factor: 21.405
Authors: Heather M Ochs-Balcom; Brydon J B Grant; Paola Muti; Christopher T Sempos; Jo L Freudenheim; Maurizio Trevisan; Patricia A Cassano; Licia Iacoviello; Holger J Schünemann Journal: Chest Date: 2006-04 Impact factor: 9.410
Authors: N H Chavannes; M J H Huibers; T R J Schermer; A Hendriks; C van Weel; E F M Wouters; C P van Schayck Journal: Fam Pract Date: 2005-07-15 Impact factor: 2.267
Authors: Theodore A Omachi; Patricia P Katz; Edward H Yelin; Steven E Gregorich; Carlos Iribarren; Paul D Blanc; Mark D Eisner Journal: Am J Med Date: 2009-08 Impact factor: 4.965
Authors: Kaitlyn B Gam; Lawrence S Engel; Richard K Kwok; Matthew D Curry; Patricia A Stewart; Mark R Stenzel; John A McGrath; W Braxton Jackson; Maureen Y Lichtveld; Dale P Sandler Journal: Environ Int Date: 2018-10-11 Impact factor: 9.621