Literature DB >> 23957500

A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

W Keith Funkhouser1, Marc Niethammer, Johnny L Carson, Kimberlie A Burns, Michael R Knowles, Margaret W Leigh, Maimoona A Zariwala, William K Funkhouser.   

Abstract

Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. The authors developed a novel image analysis tool to average the axonemal peripheral microtubular doublets, thereby increasing microtubular signal and reducing random background noise. In a randomized, double-blinded study that compared two experienced morphologists and three different diagnostic approaches, they found that use of this tool led to improvement in diagnostic TEM test performance.

Entities:  

Keywords:  PCD; Primary ciliary dyskinesia; dynein arm; image analysis

Mesh：

Substances：

Year:  2013        PMID： 23957500      PMCID： PMC3990650          DOI： 10.3109/01913123.2013.815081

Source DB:  PubMed          Journal:  Ultrastruct Pathol        ISSN： 0191-3123            Impact factor:   1.094


  30 in total

1.  Absence of axonemal arms in nasal mucosa cilia in Kartagener's syndrome.

Authors:  H Pedersen; N Mygind
Journal:  Nature       Date:  1976-08-05       Impact factor: 49.962

Review 2.  The challenges of diagnosing primary ciliary dyskinesia.

Authors:  Margaret W Leigh; Christopher O'Callaghan; Michael R Knowles
Journal:  Proc Am Thorac Soc       Date:  2011-09

3.  Purification and polypeptide composition of dynein ATPases from Chlamydomonas flagella.

Authors:  K K Pfister; R B Fay; G B Witman
Journal:  Cell Motil       Date:  1982

4.  Founder mutation in RSPH4A identified in patients of Hispanic descent with primary ciliary dyskinesia.

Authors:  M Leigh Anne Daniels; Margaret W Leigh; Stephanie D Davis; Michael C Armstrong; Johnny L Carson; Milan Hazucha; Sharon D Dell; Maria Eriksson; Francis S Collins; Michael R Knowles; Maimoona A Zariwala
Journal:  Hum Mutat       Date:  2013-08-06       Impact factor: 4.878

5.  Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.

Authors:  Lucia Bartoloni; Jean-Louis Blouin; Yanzhen Pan; Corinne Gehrig; Amit K Maiti; Nathalie Scamuffa; Colette Rossier; Mark Jorissen; Miguel Armengot; Maggie Meeks; Hannah M Mitchison; Eddie M K Chung; Celia D Delozier-Blanchet; William J Craigen; Stylianos E Antonarakis
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-25       Impact factor: 11.205

6.  A 20-year experience of electron microscopy in the diagnosis of primary ciliary dyskinesia.

Authors:  J F Papon; A Coste; F Roudot-Thoraval; M Boucherat; G Roger; A Tamalet; A M Vojtek; S Amselem; E Escudier
Journal:  Eur Respir J       Date:  2009-10-19       Impact factor: 16.671

7.  Lack of dynein arms in immotile human spermatozoa.

Authors:  B A Afzelius; R Eliasson; O Johnsen; C Lindholmer
Journal:  J Cell Biol       Date:  1975-08       Impact factor: 10.539

Review 8.  Cilia-related diseases.

Authors:  B A Afzelius
Journal:  J Pathol       Date:  2004-11       Impact factor: 7.996

9.  Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

Authors:  Dinu Antony; Anita Becker-Heck; Maimoona A Zariwala; Miriam Schmidts; Alexandros Onoufriadis; Mitra Forouhan; Robert Wilson; Theresa Taylor-Cox; Ann Dewar; Claire Jackson; Patricia Goggin; Niki T Loges; Heike Olbrich; Martine Jaspers; Mark Jorissen; Margaret W Leigh; Whitney E Wolf; M Leigh Anne Daniels; Peadar G Noone; Thomas W Ferkol; Scott D Sagel; Margaret Rosenfeld; Andrew Rutman; Abhijit Dixit; Christopher O'Callaghan; Jane S Lucas; Claire Hogg; Peter J Scambler; Richard D Emes; Eddie M K Chung; Amelia Shoemark; Michael R Knowles; Heymut Omran; Hannah M Mitchison
Journal:  Hum Mutat       Date:  2013-02-11       Impact factor: 4.878

10.  The metachronal wave of lateral cilia of Mytilus edulis.

Authors:  E Aiello; M A Sleigh
Journal:  J Cell Biol       Date:  1972-09       Impact factor: 10.539
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  4 in total

Review 1.  Prevalence of primary ciliary dyskinesia in consecutive referrals of suspect cases and the transmission electron microscopy detection rate: a systematic review and meta-analysis.

Authors:  Panayiotis Kouis; Panayiotis K Yiallouros; Nicos Middleton; John S Evans; Kyriacos Kyriacou; Stefania I Papatheodorou
Journal:  Pediatr Res       Date:  2016-12-09       Impact factor: 3.756

2.  European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia.

Authors:  Jane S Lucas; Angelo Barbato; Samuel A Collins; Myrofora Goutaki; Laura Behan; Daan Caudri; Sharon Dell; Ernst Eber; Estelle Escudier; Robert A Hirst; Claire Hogg; Mark Jorissen; Philipp Latzin; Marie Legendre; Margaret W Leigh; Fabio Midulla; Kim G Nielsen; Heymut Omran; Jean-Francois Papon; Petr Pohunek; Beatrice Redfern; David Rigau; Bernhard Rindlisbacher; Francesca Santamaria; Amelia Shoemark; Deborah Snijders; Thomy Tonia; Andrea Titieni; Woolf T Walker; Claudius Werner; Andrew Bush; Claudia E Kuehni
Journal:  Eur Respir J       Date:  2017-01-04       Impact factor: 16.671

Review 3.  Recent advances in primary ciliary dyskinesia genetics.

Authors:  Małgorzata Kurkowiak; Ewa Ziętkiewicz; Michał Witt
Journal:  J Med Genet       Date:  2014-10-28       Impact factor: 6.318

4.  Transmission electron microscopy study of suspected primary ciliary dyskinesia patients.

Authors:  Mitra Rezaei; Amirali Soheili; Seyed Ali Ziai; Atefeh Fakharian; Hossein Toreyhi; Mihan Pourabdollah; Jahangir Ghorbani; Mahboobeh Karimi-Galougahi; Seyed Alireza Mahdaviani; Maryam Hasanzad; Alireza Eslaminejad; Hossein Ali Ghaffaripour; Saied Mahmoudian; Zahra Rodafshani; Maryam Sadat Mirenayat; Mohammad Varahram; Majid Marjani; Payam Tabarsi; Davood Mansouri; Hamid Reza Jamaati; Ali Akbar Velayati
Journal:  Sci Rep       Date:  2022-02-11       Impact factor: 4.379
  4 in total

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