OBJECTIVE: The aim of this study was to elucidate the significance of tumor volume as a risk factor for predicting lymph node metastasis. METHODS: We applied the tumor volume index to the data that were collected for 327 Korean patients with endometrial cancer who underwent preoperative assessment including magnetic resonance imaging (MRI) and subsequent surgery including systematic lymphadenectomy. The volume index, which we previously reported in the literature, was defined as the product of maximum longitudinal diameter along the uterine axis, maximum anteroposterior diameter in a sagittal section image, and maximum horizontal diameter in a horizontal section image according to MRI data, from 425 Japanese women with endometrial cancer. Relationships between lymph node metastasis and results of preoperative examinations including volume index were analyzed by logistic regression analysis. RESULTS: The prevalence of affected lymph nodes was 14.2%. Multivariate analysis showed that high-grade histology assessed by endometrial biopsy [odds ratio (OR); 2.9, 95% confidence interval (CI): 1.4-6.4], volume index (OR; 2.4, 95% CI: 1.1-5.3), node enlargement assessed by MRI (OR; 4.2, 95% CI: 1.4-13.2), and high serum cancer antigen (CA)125 level (OR; 3.6, 95% CI: 1.6-8.1) were significantly and independently related to lymph node metastasis. When volume index was excluded from the analysis, myoinvasion assessed by MRI was an independent risk factor for lymph node metastasis as well as high-grade histology, node enlargement, and high serum CA125 level. CONCLUSION: Volume index is compatible with myometrial invasion as a factor for predicting lymph node metastasis in endometrial cancer.
OBJECTIVE: The aim of this study was to elucidate the significance of tumor volume as a risk factor for predicting lymph node metastasis. METHODS: We applied the tumor volume index to the data that were collected for 327 Korean patients with endometrial cancer who underwent preoperative assessment including magnetic resonance imaging (MRI) and subsequent surgery including systematic lymphadenectomy. The volume index, which we previously reported in the literature, was defined as the product of maximum longitudinal diameter along the uterine axis, maximum anteroposterior diameter in a sagittal section image, and maximum horizontal diameter in a horizontal section image according to MRI data, from 425 Japanese women with endometrial cancer. Relationships between lymph node metastasis and results of preoperative examinations including volume index were analyzed by logistic regression analysis. RESULTS: The prevalence of affected lymph nodes was 14.2%. Multivariate analysis showed that high-grade histology assessed by endometrial biopsy [odds ratio (OR); 2.9, 95% confidence interval (CI): 1.4-6.4], volume index (OR; 2.4, 95% CI: 1.1-5.3), node enlargement assessed by MRI (OR; 4.2, 95% CI: 1.4-13.2), and high serum cancer antigen (CA)125 level (OR; 3.6, 95% CI: 1.6-8.1) were significantly and independently related to lymph node metastasis. When volume index was excluded from the analysis, myoinvasion assessed by MRI was an independent risk factor for lymph node metastasis as well as high-grade histology, node enlargement, and high serum CA125 level. CONCLUSION: Volume index is compatible with myometrial invasion as a factor for predicting lymph node metastasis in endometrial cancer.
Authors: Casper Reijnen; Joanna IntHout; Leon F A G Massuger; Fleur Strobbe; Heidi V N Küsters-Vandevelde; Ingfrid S Haldorsen; Marc P L M Snijders; Johanna M A Pijnenborg Journal: Oncologist Date: 2019-06-11
Authors: Andrea Papadia; Maria Luisa Gasparri; Franziska Siegenthaler; Sara Imboden; Stefan Mohr; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2016-11-11 Impact factor: 4.553
Authors: Giorgio Bogani; Sean C Dowdy; William A Cliby; Fabio Ghezzi; Diego Rossetti; Andrea Mariani Journal: J Obstet Gynaecol Res Date: 2014-02 Impact factor: 1.730
Authors: Andrea Papadia; Alessandro Buda; Maria Luisa Gasparri; Giampaolo Di Martino; Beatrice Bussi; Debora Verri; Michael D Mueller Journal: J Cancer Res Clin Oncol Date: 2018-07-24 Impact factor: 4.553
Authors: Sigmund Ytre-Hauge; Jenny A Husby; Inger J Magnussen; Henrica M J Werner; Øyvind O Salvesen; Line Bjørge; Jone Trovik; Ingunn M Stefansson; Helga B Salvesen; Ingfrid S Haldorsen Journal: Int J Gynecol Cancer Date: 2015-03 Impact factor: 3.437