Initial management of severe hyperglycemia in patients with type 2 diabetes: an observational study.

INTRODUCTION: Current guidelines recommend insulin for patients with type 2 diabetes (T2D) and severe hyperglycemia, but this recommendation lacks sufficient evidence and poses practical challenges. It is unclear whether non-insulin treatments are effective in this setting. The objective of this study was to describe treatment strategies of T2D patients with severe hyperglycemia and identify which initial treatments, interventions, or patient characteristics correlated with successful glucose lowering.
METHODS: This was a retrospective cohort study of 114 patients with T2D and a glycosylated hemoglobin (A1C) ≥12%. Changes in A1C were compared between patients started on non-insulin medications versus insulin-based regimens. Regression analysis was performed to assess predictors of success in achieving A1C ≤9% within 1 year. The main outcomes measures were change in A1C from baseline and predictors of success in achieving A1C ≤9% within 1 year.
RESULTS: At baseline, 43 patients (37.7%) started one or more non-insulin medications; 71 (62.3%) started insulin. Fifty-eight patients (50.8%) achieved an A1C ≤9%. Predictors of success were newly diagnosed T2D, certified diabetes educator (CDE) visits, and less time to follow-up A1C; insulin therapy was not. Change in A1C was significantly better in the non-insulin cohort compared to the insulin cohort (-4.5% vs. -2.8%, p = 0.001). Newly diagnosed patients were less likely to start insulin therapy (20.8% vs. 73.3%, p < 0.001), less likely to use insulin at any point (29.2% vs 81.1%, p < 0.001), and more likely to achieve an A1C ≤9% compared to patients with established T2D (87.5% vs 41.1%, p < 0.001).
CONCLUSION: Insulin therapy was used in roughly two-thirds of patients with severe hyperglycemia, but did not result in better glycemic control compared to non-insulin regimens. Rapid follow-up, more CDE visits, and a new diabetes diagnosis were predictors of successful glucose lowering. Patients with T2D and severe hyperglycemia, particularly those newly diagnosed, may be managed with non-insulin therapy.

Introduction

Diabetes affects 25.8 million people (8.3%) in the USA. There were 1.9 million new cases diagnosed in 2010 alone [1]. While the diagnostic threshold for diabetes is an A1C ≥6.5%, patients can present with severe hyperglycemia with A1C values reaching higher than 14%. Severe hyperglycemia may warrant specific and immediate treatment considerations to prevent acute complications, alleviate symptoms, and preserve beta cell function [2, 3]. However, literature regarding the effectiveness of different treatment approaches to manage patients with non-emergent, severe hyperglycemia is limited.

The American Diabetes Association’s (ADA) position statement on a patient-centered approach to the management of hyperglycemia in type 2 diabetes recommends that “if a patient presents with significant hyperglycemic symptoms and/or has dramatically elevated plasma glucose concentrations (>300–350 mg/dL), or an A1C ≥10–12%, insulin therapy should be strongly considered from the outset” [3]. After symptoms are relieved and glucose levels are decreased, oral agents can be added and it may be possible to withdraw insulin, if preferred. This recommendation makes no distinction between newly diagnosed or drug-naïve patients and treated or established patients, and does not provide references or level of evidence.

The American Association of Clinical Endocrinologists (AACE) algorithm for glycemic control recommends insulin therapy ± other agents for patients who present with an A1C >9% [4]. The recommendations state that “for drug naïve patients with A1C levels >9%, it is unlikely that 1, 2, or even 3 agents (other than insulin) will achieve the A1C goal”. The algorithm does, however, suggest that treatment with combination non-insulin agents in drug-naïve patients who do not have symptoms may be sufficient. References or levels of evidence are not provided.

Although consensus statements suggest initiating insulin therapy, this is challenging in real-world practice. Successful insulin initiation requires time, resources, knowledge, proper dose titration, significant patient education and training, self-monitoring of blood glucose, and frequent follow-up [3]. In the primary care setting, many barriers exist, including time restraints, patient resistance, and lack of available resources and trained staff that make it difficult to initiate insulin therapy in a safe and effective manner.

The lack of sufficient evidence and the practical challenges posed by initiating insulin therapy support the need for further evaluation of treatment approaches to severe hyperglycemia in T2D patients. Therefore, the purpose of this study was to (1) describe the patient characteristics and initial management strategies of patients with T2D who presented with A1C values ≥12%, (2) compare the changes in A1C from baseline to 12 months between patients prescribed insulin-based treatment versus patients prescribed non-insulin-based treatment, and (3) identify which initial treatments, interventions, or patient characteristics correlated with clinically meaningful glycemic response.

Materials and Methods

Study Design

This study was a retrospective observational cohort study of patients with a new or established diagnosis of type 2 diabetes presenting within the University of Colorado Hospital (UCH) ambulatory clinic system with non-emergent, severe hyperglycemia, defined as a measured hemoglobin A1C of ≥12%. Clinics were primarily internal medicine and family medicine practices. The study was approved by the Colorado Multiple Institutional Review Board and the Hospital Research Review Board for the UCH. Patients with an A1C value ≥12% during the time period of January 1, 2006 to March 31, 2011 were identified. Electronic medical records (EMR) for each patient were reviewed. Data were reviewed from the date of initial presentation of patients with A1C ≥12% (defined as baseline) and followed through 1 year. Study data were collected and managed using a secure, electronic data capture tool [5]. Data collection included patient demographics (age, sex, weight, race/ethnicity, duration of diabetes, insurance status), initial treatment for diabetes within 1 month of initial presentation, diabetes medications subsequently used after 1 month, A1C values from date of initial presentation through 1 year, the number of visits with an endocrine provider or a certified diabetes educator, the number of total clinic visits with diabetes listed in the medical problem list, the number of hospitalizations or emergency department visits with diabetes listed in the medical problem list, and time to first follow-up visit after initial A1C level ≥12%.

The analysis in this article is based on previously conducted studies and does not involve any new studies of human or animal subjects performed by any of the authors.

Patient Population

Patients were included in the study if they were at least 18 years of age, had an A1C ≥12% drawn from a UCH ambulatory clinic, and had a new or established diagnosis of type 2 diabetes. Patients were excluded if they were less than 18 years of age, had type 1 diabetes, had no follow-up A1C reading within 12 months of initial presentation, were pregnant, were taking corticosteroids, or were diagnosed with stress-induced hyperglycemia, hyperglycemic hyperosmolar state, or diabetic ketoacidosis.

Study Cohorts

Clinical Response Cohorts

Patients were categorized into two cohorts based on a clinically meaningful improvement in glycemic control: (1) responders, defined as those patients who achieved an A1C ≤9% within 1 year of baseline, and (2) non-responders, those who did not achieve an A1C ≤9% within 1 year of baseline. A regression analysis was performed to identify what factors served as predictors of success in achieving an A1C ≤9%.

Initial Treatment Cohorts

Patients were stratified into two cohorts based on initial treatment medication prescribed within 1 month of baseline: (1) one or more non-insulin medications and (2) one or more insulin medications with or without non-insulin medications. Non-insulin medications included metformin, glyburide, glipizide, glimepiride, sitagliptin, saxagliptin, linagliptin, pioglitazone, rosiglitazone, repaglinide, nateglinide, acarbose, miglitol, pramlintide, liraglutide, or exenatide. Changes in A1C from baseline to 12 months were compared between the cohorts using a last observation carried forward method.

Outcomes

The outcomes of the study were: (1) descriptive results of patient characteristics and initial management strategies of patients with T2D who presented with A1C values ≥12%, (2) predictors of success that correlated with clinically meaningful glycemic response, defined as achieving an A1C ≤9% within 1 year, and (3) change in A1C from baseline to 12 months between patients prescribed insulin-based treatment versus patients prescribed non-insulin-based treatment.

Statistical Analysis

Demographic measures were summarized by their mean (SD) or n (%) for categorical measures. Comparisons of mean and categorical frequencies across the clinical response cohorts were tested using the t test or the Chi-squared test. The Welch corrected t test was used for continuous data that were not normally distributed. Comparison of baseline A1C to the end-point A1C was conducted using paired t test. Comparing changes in A1C between the cohorts was conducted using two sample t tests and the analysis of covariance (ANCOVA) model using baseline A1C and diagnosis status as covariates. These analyses were conducted using last observation carried forward. Logistic regression analysis was used to determine predictors of clinical response. Days to first follow-up, days to first A1C follow-up, number of endocrine visits, number of CDE appointments, number of other visits, insulin medication prescribed at any point during the year, and health insurance status (public or none vs. private) were considered as explanatory variables. The a priori level of significance was defined as p < 0.05. All analyses were performed using SAS 9.3 software (SAS Institute, Inc., Cary, NC, USA).

Results

A total of 242 patients were identified who presented to a UCH outpatient clinic with an A1C ≥12% during the study period. After excluding patients primarily due to type 1 diabetes diagnosis or lack of follow-up A1C, a sample of 114 patients was included in the final analysis. The average age of the patient population was 53 years, 64 (47.4%) were male, and 84 (73.7%) were non-Hispanic. The average baseline A1C was 13.1%, average weight was 91.9 kg, and average duration of diabetes was 10 years. Twenty-four patients (21.1%) did not have a previous diagnosis of T2D at the time of presenting with an A1C ≥12%. Initial treatment strategies are shown in Table 1. Within 1 month of baseline, 43 patients (37.7%) started one or more non-insulin medications rather than initiating insulin. Of those, 20 started a single non-insulin medication, the majority of which was metformin. Seventy-one patients (62.3%) initially started an insulin-based regimen.

Table 1

Initial management strategies

Initial management strategy within 1 month of baseline	Number of patients (%)
One or more non-insulin medications	43 (37.7)
Single non-insulin medication	20 (17.5)
Two or more non-insulin medications	23 (20.2)
Insulin-based regimen	71 (62.3)
Insulin plus non-insulin	43 (37.7)
Basal insulin alone	10 (8.8)
Basal plus bolus insulin	18 (15.8)

Of the 114 patients, 58 (50.8%) were classified as responders (i.e., achieved an A1C ≤9% within 1 year) and 56 (49.1%) were classified as non-responders. Comparisons between responders and non-responders are in Table 2. Responders were slightly older (54.7 vs 50.7 years, p = 0.032) and more likely to be newly diagnosed with T2D compared to non-responders (36.2% vs 5.4%, p < 0.001). Responders were less likely to initiate therapy with insulin (51.7% vs 73.2%, p = 0.019) and more likely to be initiated on a single non-insulin medication (25.9% vs 8.9%, p = 0.014). Responders were found to have significantly more visits with a CDE (1.2 ± 1.5 vs 0.4 ± 1, p = 0.002) and more likely to have fewer days to the first follow-up A1C (120 ± 72.6 vs. 154.7 ± 97.5, p = 0.033). Significantly more patients received insulin at some point in the year in the non-responder group compared to the responder group (82.1% vs 58.6%, p = 0.006).

Table 2

Comparisons between responders and non-responders

Parameter	Responders (n = 58)	Non-responders (n = 56)	p value
Mean age, years (range)	54.7 (22–74)	50.7 (28–72)	0.032
Sex, No. (% men)	27 (46.6)	27 (48.2)	0.86
Non-hispanic, no. (%)	43 (74.1)	41 (73.2)	0.91
Mean weight at baseline, kg (SD)	91.9 (32.6)	93.2 (29.0)	0.82
Insurance (non-government), no. (%)	28 (48.3)	27 (48.2)	0.99
Mean baseline A1C, % (SD)	13.2 (0.8)	13.0 (0.9)	0.28
Mean duration of diabetes, years (SD)	10.0 (7.4)	10.6 (7.0)	0.72
New T2D diagnosis at baseline, no. (%)	21 (36.2)	3 (5.4)	<0.001
Initial treatment with insulin-based regimen, no. (%)	30 (51.7)	41 (73.2)	0.019
Insulin prescribed at any point in year, no. (%)	34 (58.6)	46 (82.1)	0.006
First follow-up visit, days (SD)	42.7 (57.8)	65.0 (84.9)	0.11
First follow-up A1C, days (SD)	120.0 (72.6)	154.7 (97.5)	0.033
CDE visits, no. (SD)	1.2 (1.5)	0.4 (1.0)	0.002
Endocrine visits, no. (SD)	1.2 (1.8)	1.1 (1.6)	0.67
Other appointments, no. (SD)	4.2 (3.0)	3.8 (3.1)	0.38

A1C glycosylated hemoglobin, CDE certified diabetes educator, T2D type 2 diabetes

Results of the regression analysis to determine predictors of response are in Table 3. A new diagnosis of diabetes, less days to first A1C follow-up, and more CDE visits were found to be predictors of response, while insulin treatment and number of endocrine clinic visits were not.

Table 3

Logistic regression modeling the odds of success at any point in the year

Parameter	Odds ratio	Confidence interval	p value
Newly diagnosed	11.2	2.3–55.6	0.003
Days to first follow-up A1C	1.0	0.9–1.0	0.042
CDE visits	1.9	1.2–2.9	0.007
Endocrine visits	0.8	0.6–1.1	0.21
Insulin therapy	0.1	0.0–0.4	0.25

A1C glycosylated hemoglobin, CDE certified diabetes educator

Changes in A1C from baseline are in Table 4. The average A1C reduction in the total patient population was 3.5%. The non-insulin-treated cohort had a significantly greater reduction in A1C compared to the insulin-treated cohort (−4.5% vs −2.8%, p = 0.0011). Additionally, a significantly greater percentage of patients in the non-insulin cohort achieved an A1C ≤9% compared to the insulin-treated cohort (65.1% vs. 42.3%, p = 0.0179). Within diagnosis status subgroups (newly diagnosed vs. established diabetes), the changes in A1C from baseline were not significantly different between insulin-treated and non-insulin-treated cohorts (Table 4). In addition, the ANCOVA model showed no evidence that A1C decreases differed significantly between insulin and non-insulin use after controlling for baseline A1C and diagnosis status.

Table 4

Changes in A1C from baseline

	No.	Baseline A1C, % (SD)	Last A1C, % (SD)a	Change in A1C from baseline, % (SD)	p value
All patients	114	13.1 (0.8)	9.6 (2.5)	−3.5 (2.7)	<0.001
Treatment cohort	114				0.001
Non-insulin treated	43	13.2 (1.0)	8.6 (2.3)	−4.5 (2.6)
Insulin treated	71	13 (0.7)	10.2 (2.5)	−2.8 (2.7)
Newly diagnosed	24				0.56
Non-insulin treated	19	13.5 (1.1)	7.1 (1.2)	−6.4 (1.6)
Insulin treated	5	13.3 (0.6)	7.4 (1.3)	−5.9 (1.5)
Established diagnosis	90				0.40
Non-insulin treated	24	12.9 (0.8)	9.9 (2.2)	−3.1 (2.3)
Insulin treated	66	13 (0.7)	10.4 (2.4)	−2.6 (2.6)

A1C glycosylated hemoglobin

aA1C at month 12 or last observation carried forward

A new diagnosis of T2D at the time of presenting with an A1C ≥12% was found to be a confounding variable in the regression analysis. Therefore, additional post hoc analyses were performed to evaluate results between newly diagnosed and previously diagnosed patients. There were significantly greater reductions in A1C in newly diagnosed patients compared to patients with established diabetes (−6.3% vs. −2.7%, p = 0.001, Table 5), with A1C differences emerging within 3–5 months from baseline (Fig. 1). Twenty-one out of 24 newly diagnosed patients (87.5%) were classified as responders, achieving an A1C ≤9%, which was significantly higher than the 41.1% of patients with established diabetes (p < 0.001). In addition, 17 (70.9%) of the newly diagnosed population achieved the ADA-recommended goal A1C of ≤7% as opposed to 12 (13.3%) of previously diagnosed patients. This occurred despite the fact that newly diagnosed patients were less likely to be initially treated with insulin (20.8% vs. 73.3%, p < 0.001) or receive insulin at any point throughout the year (29.2% vs. 81.1%, p < 0.001). Of note, 16 of the 24 patients (67%) started a single non-insulin medication; 14 of those achieved an A1C ≤9% and 10 of those achieved the ADA-recommended A1C of ≤7% within a year. Details regarding the other initial treatment regimens of newly diagnosed patients are shown in Table 6.

Table 5

Comparisons between newly and previously diagnosed subjects

Parameter	Newly diagnosed (n = 24)	Previously diagnosed (n = 90)	p value
Mean baseline A1C, % (SD)	13.4 (1.0)	13 (0.7)	0.055
Change in A1C from baselinea, % (SD)	−6.3 (1.5)	−2.7 (2.5)	0.001
Respondersb, no. (%)	21 (87.5)	37 (41.1)	<0.001
Initial treatment with insulin, no. (%)	5 (20.8)	66 (73.3)	<0.001
Insulin at some point, no. (%)	7 (29.2)	73 (81.1)	<0.001
Initial treatment with one non-insulin medication, no. (%)	16 (66.7)	4 (4.4%)	<0.001
CDE visits, no. (SD)	1.2 (1.5)	0.7 (1.3)	0.13
First follow-up A1C, no. (SD)	128.8 (99.1)	139.2 (84.1)	0.64

A1C glycosylated hemoglobin, CDE certified diabetes educator

aUsing last observation carried forward

bAchieved A1C ≤9% within 1 year

Fig. 1

Mean A1C levels over 12 months. Definitions: established diagnosis (squares), new diagnosis (diamonds). *p value <0.001. A1C glycosylated hemoglobin

Table 6

A1C achievement in newly diagnosed patients based on initial treatment

Initial diabetes treatment	Achievement of A1C ≤9%, no. (%)	Achievement of A1C ≤7%, no. (%)
Total (n = 24)	21 (87.5)	17 (70.9)
One non-insulin medication (n = 16)	14 (58.3)	10 (41.7)
2 or more non-insulin medications (n = 3)	3 (12.5)	3 (12.5)
Insulin only regimen (n = 2)	1 (4.2)	1 (4.2)
Insulin + non-insulin regimen (n = 3)	3 (12.5)	3 (12.5)

A1C glycosylated hemoglobin

Discussion

This study revealed that, although clinical guidelines recommend insulin therapy for patients with T2D presenting with severe hyperglycemia, only about two-thirds of patients in this study were initiated on an insulin-based regimen. Over one-third of patients were treated with non-insulin medications with 17.5% starting on a single non-insulin medication. Regardless of adherence to guideline recommendations, 50.8% of the total population (n = 58) achieved an A1C ≤9% by the end of the year. No correlation was found between any specific medication regimen and meaningful glucose response.

The current study provides useful insight into real-world use of insulin therapy in this patient population. Overall, insulin use in the responder group was lower than anticipated with only about half initiating insulin-based therapy. In addition, patients treated with insulin were actually less likely to achieve an A1C ≤9% and had less reduction in A1C from baseline compared to non-insulin-treated patients. Possible explanations for this lack of effect with insulin include inadequate dose titration or sub-optimal adherence. Patients prescribed insulin could be more challenging to treat or more likely to have experienced past treatment failures.

This analysis did determine that more visits with a CDE was a predictor of successful glycemic response. This finding is consistent with current clinical evidence and ADA and AACE consensus statements that emphasize diabetes self-management education as a vital component of diabetes care [6-8]. Responders also had fewer days to their first follow-up A1C compared to non-responders (120.0 vs. 154.7 days). While this difference suggests that close follow-up is an important component of glycemic control, our results show that even in this high-risk population, follow-up A1C monitoring is routinely delayed past the recommended 3 months.

A new diagnosis of diabetes was a confounding variable in our analysis. Patients who were newly diagnosed were much more likely to experience success than patients with an established diagnosis of T2D. Many newly diagnosed patients experienced success despite the fact that they were more likely to start a single non-insulin medication and less likely to use insulin at any point. This finding suggests that the time of diagnosis status (i.e., new versus established diagnosis) may be a key consideration when determining treatment approaches in addition to the severity of hyperglycemia. Prospective studies evaluating the safety and efficacy of non-insulin treatment options in newly diagnosed patients with severe hyperglycemia are warranted.

Several limitations to this study exist. First, this was a retrospective study performed at a single institutional system with a relatively small sample size and may not be able to be extrapolated to all patients with T2D and severe hyperglycemia. If more patients had been included, additional predictors of response might have been identified through this analysis. Second, selection bias is also a potential limitation of this study. The initial treatment regimen prescribed to a patient could have been impacted by patient factors not evaluated in the study. For example, patients that were prescribed insulin therapy could have been more difficult to treat or could have already failed non-insulin medications, making it more difficult to attain glycemic control. In addition, medication dose adjustments and adherence were not evaluated. This is an important limitation considering that other studies have identified that the most important factor in glycemic success with insulin is intensifying therapy [9, 10]. It is highly likely that, in this real-world clinical setting, several patients in the insulin-treated cohort did not have their insulin regimen intensified sufficiently to achieve successful glycemic control. Third, we defined glycemic response as achieving an A1C ≤9% within the first year. This A1C value does not meet the general target A1C recommended by the ADA, but was determined by the authors, a priori, to constitute a clinically meaningful A1C reduction in this severe hyperglycemia population. Fourth, subjects were regarded as an “intent to treat” population. If a patient started therapy with a non-insulin medication within 1 month of baseline, they remained in the non-insulin cohort throughout analysis, regardless of whether they later received insulin medications.

Conclusion

The results from this retrospective study show that a new diagnosis of diabetes, more visits with a certified diabetes educator, and fewer days to first follow-up A1C were predictors of success in achieving an A1C ≤9%, whereas insulin therapy was not. Furthermore, it was observed that insulin therapy did not lead to better A1C reductions or higher odds of achieving an A1C ≤9% compared to non-insulin regimens, regardless if the patient was newly diagnosed or had an established diagnosis. A new diagnosis of diabetes was a confounding variable. Meaningful glucose reductions were much more likely in newly diagnosed patients than those with established diabetes regardless of the treatment approach. Despite limitations, this study suggests that patients with T2D and severe hyperglycemia, particularly those newly diagnosed, may be able to be managed with non-insulin therapy. Further randomized prospective studies are warranted to confirm this.