Literature DB >> 23948295

IL-11: a prominent pro-tumorigenic member of the IL-6 family.

Sergei I Grivennikov1.   

Abstract

Cytokines have recently emerged as important players in tumor promotion and progression. In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework for its potential inhibition in a variety of human cancers.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23948295      PMCID： PMC3855069          DOI： 10.1016/j.ccr.2013.07.018

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer.

Authors:  Bo Hu; Eran Elinav; Samuel Huber; Till Strowig; Liming Hao; Anja Hafemann; Chengcheng Jin; Claudia Wunderlich; Thomas Wunderlich; Stephanie C Eisenbarth; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-21       Impact factor: 11.205

2.  TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

Authors:  Christoph Becker; Massimo C Fantini; Christoph Schramm; Hans A Lehr; Stefan Wirtz; Alexei Nikolaev; Jürgen Burg; Susanne Strand; Ralf Kiesslich; Samuel Huber; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Peter R Galle; Manfred Blessing; Stefan Rose-John; Markus F Neurath
Journal:  Immunity       Date:  2004-10       Impact factor: 31.745

3.  mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.

Authors:  Stefan Thiem; Thomas P Pierce; Michelle Palmieri; Tracy L Putoczki; Michael Buchert; Adele Preaudet; Ryan O Farid; Chris Love; Bruno Catimel; Zhengdeng Lei; Steve Rozen; Veena Gopalakrishnan; Fred Schaper; Michael Hallek; Alex Boussioutas; Patrick Tan; Andrew Jarnicki; Matthias Ernst
Journal:  J Clin Invest       Date:  2013-01-16       Impact factor: 14.808

4.  gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

Authors:  Julia Bollrath; Toby J Phesse; Vivian A von Burstin; Tracy Putoczki; Moritz Bennecke; Trudie Bateman; Tim Nebelsiek; Therese Lundgren-May; Ozge Canli; Sarah Schwitalla; Vance Matthews; Roland M Schmid; Thomas Kirchner; Melek C Arkan; Matthias Ernst; Florian R Greten
Journal:  Cancer Cell       Date:  2009-02-03       Impact factor: 31.743

5.  IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

Authors:  Sergei Grivennikov; Eliad Karin; Janos Terzic; Daniel Mucida; Guann-Yi Yu; Sivakumar Vallabhapurapu; Jürgen Scheller; Stefan Rose-John; Hilde Cheroutre; Lars Eckmann; Michael Karin
Journal:  Cancer Cell       Date:  2009-02-03       Impact factor: 31.743

6.  Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation.

Authors:  Alexandre Calon; Elisa Espinet; Sergio Palomo-Ponce; Daniele V F Tauriello; Mar Iglesias; María Virtudes Céspedes; Marta Sevillano; Cristina Nadal; Peter Jung; Xiang H-F Zhang; Daniel Byrom; Antoni Riera; David Rossell; Ramón Mangues; Joan Massagué; Elena Sancho; Eduard Batlle
Journal:  Cancer Cell       Date:  2012-11-13       Impact factor: 31.743

Review 7.  STATs in cancer inflammation and immunity: a leading role for STAT3.

Authors:  Hua Yu; Drew Pardoll; Richard Jove
Journal:  Nat Rev Cancer       Date:  2009-11       Impact factor: 60.716

8.  STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

Authors:  Matthias Ernst; Meri Najdovska; Dianne Grail; Therese Lundgren-May; Michael Buchert; Hazel Tye; Vance B Matthews; Jane Armes; Prithi S Bhathal; Norman R Hughes; Eric G Marcusson; James G Karras; Songqing Na; Jonathon D Sedgwick; Paul J Hertzog; Brendan J Jenkins
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808

9.  Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

Authors:  Tracy L Putoczki; Stefan Thiem; Andrea Loving; Rita A Busuttil; Nicholas J Wilson; Paul K Ziegler; Paul M Nguyen; Adele Preaudet; Ryan Farid; Kirsten M Edwards; Yeliz Boglev; Rodney B Luwor; Andrew Jarnicki; David Horst; Alex Boussioutas; Joan K Heath; Oliver M Sieber; Irina Pleines; Benjamin T Kile; Andrew Nash; Florian R Greten; Brent S McKenzie; Matthias Ernst
Journal:  Cancer Cell       Date:  2013-08-12       Impact factor: 31.743

10.  IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

Authors:  Samuel Huber; Nicola Gagliani; Lauren A Zenewicz; Francis J Huber; Lidia Bosurgi; Bo Hu; Matija Hedl; Wei Zhang; William O'Connor; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Carmen J Booth; Judy H Cho; Wenjun Ouyang; Clara Abraham; Richard A Flavell
Journal:  Nature       Date:  2012-10-17       Impact factor: 49.962
  10 in total
  17 in total

Review 1.  Cancer and the microbiota.

Authors:  Wendy S Garrett
Journal:  Science       Date:  2015-04-03       Impact factor: 47.728

2.  IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model.

Authors:  H Kitamura; Y Onodera; S Murakami; T Suzuki; H Motohashi
Journal:  Oncogene       Date:  2017-07-17       Impact factor: 9.867

Review 3.  Revisiting STAT3 signalling in cancer: new and unexpected biological functions.

Authors:  Hua Yu; Heehyoung Lee; Andreas Herrmann; Ralf Buettner; Richard Jove
Journal:  Nat Rev Cancer       Date:  2014-11       Impact factor: 60.716

4.  YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Authors:  Koji Taniguchi; Toshiro Moroishi; Petrus R de Jong; Michal Krawczyk; Britta Moyo Grebbin; Huiyan Luo; Rui-Hua Xu; Nicole Golob-Schwarzl; Caroline Schweiger; Kepeng Wang; Giuseppe Di Caro; Ying Feng; Eric R Fearon; Eyal Raz; Lukas Kenner; Henner F Farin; Kun-Liang Guan; Johannes Haybaeck; Christian Datz; Kang Zhang; Michael Karin
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-27       Impact factor: 11.205

5.  Treatment of CIA Mice with FGF21 Down-regulates TH17-IL-17 Axis.

Authors:  Si-Ming Li; Yin-Hang Yu; Lu Li; Wen-Fei Wang; De-Shan Li
Journal:  Inflammation       Date:  2016-02       Impact factor: 4.092

6.  Elevated serum IL-11, TNF α, and VEGF expressions contribute to the pathophysiology of hypertensive intracerebral hemorrhage (HICH).

Authors:  Gang Yang; Gao-Feng Shao
Journal:  Neurol Sci       Date:  2016-04-26       Impact factor: 3.307

Review 7.  The therapeutic value of targeting inflammation in gastrointestinal cancers.

Authors:  Beicheng Sun; Michael Karin
Journal:  Trends Pharmacol Sci       Date:  2014-05-28       Impact factor: 14.819

Review 8.  Interleukins in cancer: from biology to therapy.

Authors:  Daria Briukhovetska; Janina Dörr; Stefan Endres; Peter Libby; Charles A Dinarello; Sebastian Kobold
Journal:  Nat Rev Cancer       Date:  2021-06-03       Impact factor: 69.800

9.  MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.

Authors:  Chenfei Zhou; Jun Ji; Qu Cai; Min Shi; Xuehua Chen; Yingyan Yu; Zhenggang Zhu; Jun Zhang
Journal:  BMC Cancer       Date:  2015-05-02       Impact factor: 4.430

Review 10.  Clinical Application of Cytokines in Cancer Immunotherapy.

Authors:  Yi Qiu; Mengxi Su; Leyi Liu; Yiqi Tang; Yuan Pan; Jianbo Sun
Journal:  Drug Des Devel Ther       Date:  2021-05-27       Impact factor: 4.162
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