Literature DB >> 24881011

The therapeutic value of targeting inflammation in gastrointestinal cancers.

Beicheng Sun1, Michael Karin2.   

Abstract

Inflammation has been implicated in the initiation and progression of gastrointestinal (GI) cancers. Inflammation also plays important roles in subverting immune tolerance, escape from immune surveillance, and conferring resistance to chemotherapeutic agents. Targeting key regulators and mediators of inflammation represents an attractive strategy for GI cancer prevention and treatment. However, the targeting of inflammation in GI cancer is not straightforward and sometimes inflammation may contribute to tumor regression. We discuss the origins and effects of inflammation in GI cancer and how to target it successfully.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cytokines; targeting therapy; tumor initiation; tumor promotion

Mesh：

Substances：

Year:  2014        PMID： 24881011      PMCID： PMC4108072          DOI： 10.1016/j.tips.2014.04.011

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  104 in total

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