BACKGROUND: The effect of body mass index (BMI) on the prognosis of metastatic breast cancer (MBC) has not been explored so far. METHODS: The relationship between BMI (kg/m(2)) and progression-free survival (PFS) or overall survival (OS) was assessed in 489 patients with MBC enrolled in three clinical trials of first-line chemotherapy. World Health Organization BMI categories were used: normal, 18.5-24.9 kg/m(2); overweight, 25-29.9 kg/m(2); and obese, 30+ kg/m(2). Univariate PFS and OS curves were estimated; multivariate Cox analysis was conducted adjusting for age, menopausal status, performance status (PS), hormonal status and site, and number of metastases. RESULTS: Overall, 39.9% of the patients were normal or underweight, 37.8% were overweight, and 22.3% were obese. Median age was 57 years (range 25-73); median PS was 0. Median PFS was 10.9 months [interquartile range (IQR) 5.5 to 19.9] in normal weight women, 13.0 months (IQR 7.8 to 23.7) in overweight, and 12.2 (IQR 7.1 to 23.0) in obese women, P = 0.17. Median OS was 32.0 months [95% confidence interval (CI), 14.5-88.3] versus 33.2 months (95% CI, 19.4-81.1) and 30.7 (95% CI, 17.6-50.8), respectively. In multivariate analyses, no statistically significant association between BMI category and PFS or OS was observed. CONCLUSIONS: In this study, BMI was not associated with the outcome of patients with MBC treated with first-line chemotherapy. IMPACT: In the absence of any evidence in support of a prognostic role of obesity in patients with MBC treated with chemotherapy, dietary restrictions, medical interventions aimed at reducing BMI/insulin resistance, or specific anticancer treatment strategies do not seem to be appropriate.
BACKGROUND: The effect of body mass index (BMI) on the prognosis of metastatic breast cancer (MBC) has not been explored so far. METHODS: The relationship between BMI (kg/m(2)) and progression-free survival (PFS) or overall survival (OS) was assessed in 489 patients with MBC enrolled in three clinical trials of first-line chemotherapy. World Health Organization BMI categories were used: normal, 18.5-24.9 kg/m(2); overweight, 25-29.9 kg/m(2); and obese, 30+ kg/m(2). Univariate PFS and OS curves were estimated; multivariate Cox analysis was conducted adjusting for age, menopausal status, performance status (PS), hormonal status and site, and number of metastases. RESULTS: Overall, 39.9% of the patients were normal or underweight, 37.8% were overweight, and 22.3% were obese. Median age was 57 years (range 25-73); median PS was 0. Median PFS was 10.9 months [interquartile range (IQR) 5.5 to 19.9] in normal weight women, 13.0 months (IQR 7.8 to 23.7) in overweight, and 12.2 (IQR 7.1 to 23.0) in obesewomen, P = 0.17. Median OS was 32.0 months [95% confidence interval (CI), 14.5-88.3] versus 33.2 months (95% CI, 19.4-81.1) and 30.7 (95% CI, 17.6-50.8), respectively. In multivariate analyses, no statistically significant association between BMI category and PFS or OS was observed. CONCLUSIONS: In this study, BMI was not associated with the outcome of patients with MBC treated with first-line chemotherapy. IMPACT: In the absence of any evidence in support of a prognostic role of obesity in patients with MBC treated with chemotherapy, dietary restrictions, medical interventions aimed at reducing BMI/insulin resistance, or specific anticancer treatment strategies do not seem to be appropriate.
Authors: Laura Pizzuti; Domenico Sergi; Isabella Sperduti; Luigi Di Lauro; Marco Mazzotta; Claudio Botti; Fiorentino Izzo; Luca Marchetti; Silverio Tomao; Paolo Marchetti; Clara Natoli; Antonino Grassadonia; Teresa Gamucci; Lucia Mentuccia; Emanuela Magnolfi; Angela Vaccaro; Alessandra Cassano; Ernesto Rossi; Andrea Botticelli; Valentina Sini; Maria G Sarobba; Maria Agnese Fabbri; Luca Moscetti; Antonio Astone; Andrea Michelotti; Claudia De Angelis; Ilaria Bertolini; Francesco Angelini; Gennaro Ciliberto; Marcello Maugeri-Saccà; Antonio Giordano; Maddalena Barba; Patrizia Vici Journal: Cancer Biol Ther Date: 2018-02-16 Impact factor: 4.742
Authors: Jennifer A Ligibel; Luke Huebner; Hope S Rugo; Harold J Burstein; Debra L Toppmeyer; Carey K Anders; Cynthia Ma; William T Barry; Vera Suman; Lisa A Carey; Ann H Partridge; Clifford A Hudis; Eric P Winer Journal: JNCI Cancer Spectr Date: 2021-04-12
Authors: Natansh D Modi; Jin Quan Eugene Tan; Andrew Rowland; Bogda Koczwara; Ahmad Y Abuhelwa; Ganessan Kichenadasse; Ross A McKinnon; Michael D Wiese; Michael J Sorich; Ashley M Hopkins Journal: NPJ Breast Cancer Date: 2021-03-22