Literature DB >> 23943613

From natural product-inspired pyrrolidine scaffolds to the development of new human Golgi α-mannosidase II inhibitors.

Ting-Jen R Cheng1, Ting-Hao Chan, En-Lun Tsou, Shang-Yu Chang, Wen-Yi Yun, Pei-Jung Yang, Ying-Ta Wu, Wei-Chieh Cheng.   

Abstract

Entities:  

Keywords:  alkaloids; combinatorial chemistry; natural products; pyrrolidine-based scaffold; synthetic inhibitors

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Year:  2013        PMID： 23943613     DOI： 10.1002/asia.201300680

Source DB:  PubMed          Journal:  Chem Asian J        ISSN： 1861-471X


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  3 in total

1.  Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents.

Authors:  Wei-An Chen; Yu-Hsin Chen; Chiao-Yun Hsieh; Pi-Fang Hung; Chiao-Wen Chen; Chien-Hung Chen; Jung-Lee Lin; Ting-Jen R Cheng; Tsui-Ling Hsu; Ying-Ta Wu; Chia-Ning Shen; Wei-Chieh Cheng
Journal:  Chem Sci       Date:  2022-04-19       Impact factor: 9.969

2.  Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design.

Authors:  Lina Irsheid; Thomas Wehler; Christoph Borek; Werner Kiefer; Ruth Brenk; Maria Elena Ortiz-Soto; Jürgen Seibel; Tanja Schirmeister
Journal:  PLoS One       Date:  2019-05-08       Impact factor: 3.240

3.  Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent β-N-Acetylhexosaminidase Inhibition.

Authors:  Xin Yan; Yuna Shimadate; Atsushi Kato; Yi-Xian Li; Yue-Mei Jia; George W J Fleet; Chu-Yi Yu
Journal:  Molecules       Date:  2020-03-25       Impact factor: 4.411
  3 in total

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