PURPOSE: To compare two methods of composite score generation in dry eye syndrome (DES). METHODS: Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). RESULTS: A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40%. CONCLUSIONS: Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.
PURPOSE: To compare two methods of composite score generation in dry eye syndrome (DES). METHODS: Male patients seen in the Miami Veterans Affairs eye clinic with normal eyelid, corneal, and conjunctival anatomy were recruited to participate in the study. Patients filled out the Dry Eye Questionnaire 5 (DEQ5) and underwent measurement of tear film parameters. DES severity scores were generated by independent component analysis (ICA) and latent class analysis (LCA). RESULTS: A total of 247 men were included in the study. Mean age was 69 years (SD 9). Using ICA analysis, osmolarity was found to carry the largest weight, followed by eyelid vascularity and meibomian orifice plugging. Conjunctival injection and tear breakup time (TBUT) carried the lowest weights. Using LCA analysis, TBUT was found to be best at discriminating healthy from diseased eyes, followed closely by Schirmer's test. DEQ5, eyelid vascularity, and conjunctival injection were the poorest at discrimination. The adjusted correlation coefficient between the two generated composite scores was 0.63, indicating that the shared variance was less than 40%. CONCLUSIONS: Both ICA and LCA produced composite scores for dry eye severity, with weak to moderate agreement; however, agreement for the relative importance of single diagnostic tests was poor between the two methods.
Authors: Krithika Rajagopalan; Linda Abetz; Polyxane Mertzanis; Derek Espindle; Carolyn Begley; Robin Chalmers; Barbara Caffery; Christopher Snyder; J Daniel Nelson; Trefford Simpson; Timothy Edrington Journal: Value Health Date: 2005 Mar-Apr Impact factor: 5.725
Authors: Craig W See; Wondu Alemayehu; Muluken Melese; Zhaoxia Zhou; Travis C Porco; Stephen Shiboski; Bruce D Gaynor; John Eng; Jeremy D Keenan; Thomas M Lietman Journal: Invest Ophthalmol Vis Sci Date: 2011-08-03 Impact factor: 4.799
Authors: Anat Galor; William Feuer; David J Lee; Hermes Florez; Vincent D Venincasa; Victor L Perez Journal: Invest Ophthalmol Vis Sci Date: 2013-02-19 Impact factor: 4.799
Authors: Steven Boker; Michael Neale; Hermine Maes; Michael Wilde; Michael Spiegel; Timothy Brick; Jeffrey Spies; Ryne Estabrook; Sarah Kenny; Timothy Bates; Paras Mehta; John Fox Journal: Psychometrika Date: 2011-04-01 Impact factor: 2.500
Authors: Patrick M Azcarate; Vincent D Venincasa; William Feuer; Frank Stanczyk; Andrew V Schally; Anat Galor Journal: Invest Ophthalmol Vis Sci Date: 2014-07-03 Impact factor: 4.799