We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae.
We recently described the isolation of a novel pan class="Species">influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to humaninfluenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and humaninfluenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and humaninfluenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae.
Authors: Delphine Guilligay; Franck Tarendeau; Patricia Resa-Infante; Rocío Coloma; Thibaut Crepin; Peter Sehr; Joe Lewis; Rob W H Ruigrok; Juan Ortin; Darren J Hart; Stephen Cusack Journal: Nat Struct Mol Biol Date: 2008-05-04 Impact factor: 15.369
Authors: A S Gambaryan; V P Marinina; A B Tuzikov; N V Bovin; I A Rudneva; B V Sinitsyn; A A Shilov; M N Matrosovich Journal: Virology Date: 1998-08-01 Impact factor: 3.616
Authors: W Poeppl; M Hell; H Herkner; B Stoiser; G Fritsche; N Schurz-Bamieh; G Poeppl; R Gattringer; N Jones; M Maass; A Egle; H Burgmann Journal: Infection Date: 2011-05-05 Impact factor: 3.553
Authors: Ben M Hause; Mariette Ducatez; Emily A Collin; Zhiguang Ran; Runxia Liu; Zizhang Sheng; Anibal Armien; Bryan Kaplan; Suvobrata Chakravarty; Adam D Hoppe; Richard J Webby; Randy R Simonson; Feng Li Journal: PLoS Pathog Date: 2013-02-07 Impact factor: 6.823
Authors: Terry Fei Fan Ng; Nikola O Kondov; Xutao Deng; Alison Van Eenennaam; Holly L Neibergs; Eric Delwart Journal: J Virol Date: 2015-03-04 Impact factor: 5.103
Authors: Junrong Luo; Lucas Ferguson; David R Smith; Amelia R Woolums; William B Epperson; Xiu-Feng Wan Journal: Virology Date: 2016-11-23 Impact factor: 3.616
Authors: Runxia Liu; Zizhang Sheng; Tao Lin; Chithra Sreenivasan; Rongruan Gao; Milton Thomas; Julian Druce; Ben M Hause; Radhey S Kaushik; Feng Li; Dan Wang Journal: J Med Virol Date: 2019-09-23 Impact factor: 2.327
Authors: Lucas Ferguson; Laura Eckard; William B Epperson; Li-Ping Long; David Smith; Carla Huston; Suzanne Genova; Richard Webby; Xiu-Feng Wan Journal: Virology Date: 2015-09-18 Impact factor: 3.616