BACKGROUND: Long interspersed nucleotide element-1 (LINE-1) retrotransposons are located throughout the human genome. Those retaining an intact 5' promoter can copy and insert themselves into the DNA of neural progenitor cells that express tyrosine hydroxylase, which may influence differentiation and survival of these cells. LINE-1 promoter methylation is associated with decreased LINE-1 propagation. OBJECTIVE: To investigate whether LINE-1 promoter methylation is associated with Parkinson's disease (PD). METHODS: We compared LINE-1 methylation profiles in blood mononuclear cells between 292 newly diagnosed PD cases and 401 unrelated, neurologically normal controls, all non-Hispanic Caucasians in western Washington state. RESULTS: Overall, PD was not associated with percent methylation of the LINE-1 promoter. However, the predictable inverse association between PD and ever smoking tobacco was strongest for men and women with the lowest LINE-1 promoter methylation, and less apparent as LINE-1 methylation increased. Underlying this possible interaction, ever regularly smoking tobacco was associated with decreased LINE-1 methylation in controls (age- and sex-adjusted linear regression β = -0.24, 95% confidence interval [CI] -0.43, -0.04), but not in cases (β = 0.06, 95% CI -0.17, 0.28, interaction p = 0.06). CONCLUSION: PD cases may have innate differences in their ability to respond to tobacco smoke.
BACKGROUND: Long interspersed nucleotide element-1 (LINE-1) retrotransposons are located throughout the human genome. Those retaining an intact 5' promoter can copy and insert themselves into the DNA of neural progenitor cells that express tyrosine hydroxylase, which may influence differentiation and survival of these cells. LINE-1 promoter methylation is associated with decreased LINE-1 propagation. OBJECTIVE: To investigate whether LINE-1 promoter methylation is associated with Parkinson's disease (PD). METHODS: We compared LINE-1 methylation profiles in blood mononuclear cells between 292 newly diagnosed PD cases and 401 unrelated, neurologically normal controls, all non-Hispanic Caucasians in western Washington state. RESULTS: Overall, PD was not associated with percent methylation of the LINE-1 promoter. However, the predictable inverse association between PD and ever smoking tobacco was strongest for men and women with the lowest LINE-1 promoter methylation, and less apparent as LINE-1 methylation increased. Underlying this possible interaction, ever regularly smoking tobacco was associated with decreased LINE-1 methylation in controls (age- and sex-adjusted linear regression β = -0.24, 95% confidence interval [CI] -0.43, -0.04), but not in cases (β = 0.06, 95% CI -0.17, 0.28, interaction p = 0.06). CONCLUSION:PD cases may have innate differences in their ability to respond to tobacco smoke.
Authors: Zhong-Zheng Zhu; Lifang Hou; Valentina Bollati; Letizia Tarantini; Barbara Marinelli; Laura Cantone; Allen S Yang; Pantel Vokonas; Jolanta Lissowska; Silvia Fustinoni; Angela C Pesatori; Matteo Bonzini; Pietro Apostoli; Giovanni Costa; Pier Alberto Bertazzi; Wong-Ho Chow; Joel Schwartz; Andrea Baccarelli Journal: Int J Epidemiol Date: 2010-09-15 Impact factor: 7.196
Authors: F Liu; J K Killian; M Yang; R L Walker; J A Hong; M Zhang; S Davis; Y Zhang; M Hussain; S Xi; M Rao; P A Meltzer; D S Schrump Journal: Oncogene Date: 2010-05-03 Impact factor: 9.867
Authors: Charlotte S Wilhelm; Karl T Kelsey; Rondi Butler; Silvia Plaza; Luc Gagne; M Scot Zens; Angeline S Andrew; Steven Morris; Heather H Nelson; Alan R Schned; Margaret R Karagas; Carmen J Marsit Journal: Clin Cancer Res Date: 2010-02-23 Impact factor: 12.531
Authors: Dana van Bemmel; Petra Lenz; Linda M Liao; Dalsu Baris; Lawrence R Sternberg; Andrew Warner; Alison Johnson; Michael Jones; Masatoshi Kida; Molly Schwenn; Alan R Schned; Debra T Silverman; Nathaniel Rothman; Lee E Moore Journal: Cancer Epidemiol Biomarkers Prev Date: 2012-04-26 Impact factor: 4.254
Authors: Haley L Cash; Li Tao; Jian-Min Yuan; Carmen J Marsit; E Andres Houseman; Yong-Bing Xiang; Yu-Tang Gao; Heather H Nelson; Karl T Kelsey Journal: Int J Cancer Date: 2011-05-25 Impact factor: 7.396
Authors: Jennifer A Rusiecki; Ligong Chen; Vasantha Srikantan; Lei Zhang; Liying Yan; Matthew L Polin; Andrea Baccarelli Journal: Epigenomics Date: 2012-02 Impact factor: 4.778
Authors: Ivo Teneng; Diego E Montoya-Durango; James L Quertermous; Mary E Lacy; Kenneth S Ramos Journal: Epigenetics Date: 2011-03-01 Impact factor: 4.528
Authors: Susan Searles Nielsen; Lisa G Gallagher; Jessica I Lundin; W T Longstreth; Terri Smith-Weller; Gary M Franklin; Phillip D Swanson; Harvey Checkoway Journal: Mov Disord Date: 2011-11-16 Impact factor: 10.338
Authors: Valentina Bollati; Andrea Baccarelli; Lifang Hou; Matteo Bonzini; Silvia Fustinoni; Domenico Cavallo; Hyang-Min Byun; Jiayi Jiang; Barbara Marinelli; Angela C Pesatori; Pier A Bertazzi; Allen S Yang Journal: Cancer Res Date: 2007-02-01 Impact factor: 12.701
Authors: Susan Searles Nielsen; Theo K Bammler; Lisa G Gallagher; Federico M Farin; Wt Longstreth; Gary M Franklin; Phillip D Swanson; Harvey Checkoway Journal: Int J Mol Epidemiol Genet Date: 2013-03-18
Authors: Susan Searles Nielsen; Gary M Franklin; W T Longstreth; Phillip D Swanson; Harvey Checkoway Journal: Ann Neurol Date: 2013-05-09 Impact factor: 10.422
Authors: Ismaïl Ahmed; Pei-Chen Lee; Christina M Lill; Susan Searles Nielsen; Fanny Artaud; Lisa G Gallagher; Marie-Anne Loriot; Claire Mulot; Magali Nacfer; Tian Liu; Joanna M Biernacka; Sebastian Armasu; Kari Anderson; Federico M Farin; Christina Funch Lassen; Johnni Hansen; Jørgen H Olsen; Lars Bertram; Demetrius M Maraganore; Harvey Checkoway; Beate Ritz; Alexis Elbaz Journal: PLoS Genet Date: 2014-11-20 Impact factor: 5.917
Authors: Ke-Xin Wen; Jelena Miliç; Bassem El-Khodor; Klodian Dhana; Jana Nano; Tammy Pulido; Bledar Kraja; Asija Zaciragic; Wichor M Bramer; John Troup; Rajiv Chowdhury; M Arfam Ikram; Abbas Dehghan; Taulant Muka; Oscar H Franco Journal: PLoS One Date: 2016-12-14 Impact factor: 3.240