PURPOSE: To estimate the age- and sex-specific prevalence of early age-related macular degeneration (AMD; drusen and retinal pigment abnormalities) and late AMD (exudative AMD and geographic atrophy) in the Japanese population. DESIGN: Community-based, cross-sectional study. METHODS: The study was held in Nagahama, Japan, and included 6065 Japanese individuals (aged ≥50 years) recruited in 2008-2010. We graded fundus photographs of both eyes for the AMD phenotype based on drusen size, the presence of retinal pigment abnormalities, and late AMD. The associations between smoking and AMD phenotypes were also evaluated. RESULTS: We assessed 5595 subjects (women, 65%) with a gradable macular condition. Early and late AMD prevalence increased from 16.1% and 0.27% at 50-59 years to 31.2% and 0.98%, respectively, at 70-74 years and was predominant in male subjects in each age group. Smoking was associated with both early and late AMD stages and retinal pigment abnormalities (P < .0001), but not with drusen (P = .305). The prevalence of retinal pigment abnormalities was significantly higher in men (P < .0001), which was associated with high rates of cigarette smoking. We found no sex difference for the prevalence of large drusen (P = .264). CONCLUSIONS: The prevalence of early AMD among adult Japanese persons was similar to the rates in white populations. The prevalence of late AMD in Japanese people aged <70 years was similar to that observed in white populations, whereas that in Japanese people aged ≥70 years was relatively lower.
PURPOSE: To estimate the age- and sex-specific prevalence of early age-related macular degeneration (AMD; drusen and retinal pigment abnormalities) and late AMD (exudative AMD and geographic atrophy) in the Japanese population. DESIGN: Community-based, cross-sectional study. METHODS: The study was held in Nagahama, Japan, and included 6065 Japanese individuals (aged ≥50 years) recruited in 2008-2010. We graded fundus photographs of both eyes for the AMD phenotype based on drusen size, the presence of retinal pigment abnormalities, and late AMD. The associations between smoking and AMD phenotypes were also evaluated. RESULTS: We assessed 5595 subjects (women, 65%) with a gradable macular condition. Early and late AMD prevalence increased from 16.1% and 0.27% at 50-59 years to 31.2% and 0.98%, respectively, at 70-74 years and was predominant in male subjects in each age group. Smoking was associated with both early and late AMD stages and retinal pigment abnormalities (P < .0001), but not with drusen (P = .305). The prevalence of retinal pigment abnormalities was significantly higher in men (P < .0001), which was associated with high rates of cigarette smoking. We found no sex difference for the prevalence of large drusen (P = .264). CONCLUSIONS: The prevalence of early AMD among adult Japanese persons was similar to the rates in white populations. The prevalence of late AMD in Japanese people aged <70 years was similar to that observed in white populations, whereas that in Japanese people aged ≥70 years was relatively lower.
Authors: T Nakama; S Yoshida; K Ishikawa; Y Kobayashi; Y Zhou; S Nakao; Y Sassa; Y Oshima; K Takao; A Shimahara; K Yoshikawa; T Hamasaki; T Ohgi; H Hayashi; A Matsuda; A Kudo; M Nozaki; Y Ogura; M Kuroda; T Ishibashi Journal: Gene Ther Date: 2014-12-11 Impact factor: 5.250
Authors: Masahiro Miyake; Kenji Yamashiro; Yasuharu Tabara; Kenji Suda; Satoshi Morooka; Hideo Nakanishi; Chiea-Chuen Khor; Peng Chen; Fan Qiao; Isao Nakata; Yumiko Akagi-Kurashige; Norimoto Gotoh; Akitaka Tsujikawa; Akira Meguro; Sentaro Kusuhara; Ozen Polasek; Caroline Hayward; Alan F Wright; Harry Campbell; Andrea J Richardson; Maria Schache; Masaki Takeuchi; David A Mackey; Alex W Hewitt; Gabriel Cuellar; Yi Shi; Luling Huang; Zhenglin Yang; Kim Hung Leung; Patrick Y P Kao; Maurice K H Yap; Shea Ping Yip; Muka Moriyama; Kyoko Ohno-Matsui; Nobuhisa Mizuki; Stuart MacGregor; Veronique Vitart; Tin Aung; Seang-Mei Saw; E-Shyong Tai; Tien Yin Wong; Ching-Yu Cheng; Paul N Baird; Ryo Yamada; Fumihiko Matsuda; Nagahisa Yoshimura Journal: Nat Commun Date: 2015-03-31 Impact factor: 14.919
Authors: Qiao Fan; Virginie J M Verhoeven; Robert Wojciechowski; Veluchamy A Barathi; Pirro G Hysi; Jeremy A Guggenheim; René Höhn; Veronique Vitart; Anthony P Khawaja; Kenji Yamashiro; S Mohsen Hosseini; Terho Lehtimäki; Yi Lu; Toomas Haller; Jing Xie; Cécile Delcourt; Mario Pirastu; Juho Wedenoja; Puya Gharahkhani; Cristina Venturini; Masahiro Miyake; Alex W Hewitt; Xiaobo Guo; Johanna Mazur; Jenifer E Huffman; Katie M Williams; Ozren Polasek; Harry Campbell; Igor Rudan; Zoran Vatavuk; James F Wilson; Peter K Joshi; George McMahon; Beate St Pourcain; David M Evans; Claire L Simpson; Tae-Hwi Schwantes-An; Robert P Igo; Alireza Mirshahi; Audrey Cougnard-Gregoire; Céline Bellenguez; Maria Blettner; Olli Raitakari; Mika Kähönen; Ilkka Seppala; Tanja Zeller; Thomas Meitinger; Janina S Ried; Christian Gieger; Laura Portas; Elisabeth M van Leeuwen; Najaf Amin; André G Uitterlinden; Fernando Rivadeneira; Albert Hofman; Johannes R Vingerling; Ya Xing Wang; Xu Wang; Eileen Tai-Hui Boh; M Kamran Ikram; Charumathi Sabanayagam; Preeti Gupta; Vincent Tan; Lei Zhou; Candice E H Ho; Wan'e Lim; Roger W Beuerman; Rosalynn Siantar; E-Shyong Tai; Eranga Vithana; Evelin Mihailov; Chiea-Chuen Khor; Caroline Hayward; Robert N Luben; Paul J Foster; Barbara E K Klein; Ronald Klein; Hoi-Suen Wong; Paul Mitchell; Andres Metspalu; Tin Aung; Terri L Young; Mingguang He; Olavi Pärssinen; Cornelia M van Duijn; Jie Jin Wang; Cathy Williams; Jost B Jonas; Yik-Ying Teo; David A Mackey; Konrad Oexle; Nagahisa Yoshimura; Andrew D Paterson; Norbert Pfeiffer; Tien-Yin Wong; Paul N Baird; Dwight Stambolian; Joan E Bailey Wilson; Ching-Yu Cheng; Christopher J Hammond; Caroline C W Klaver; Seang-Mei Saw; Jugnoo S Rahi; Jean-François Korobelnik; John P Kemp; Nicholas J Timpson; George Davey Smith; Jamie E Craig; Kathryn P Burdon; Rhys D Fogarty; Sudha K Iyengar; Emily Chew; Sarayut Janmahasatian; Nicholas G Martin; Stuart MacGregor; Liang Xu; Maria Schache; Vinay Nangia; Songhomitra Panda-Jonas; Alan F Wright; Jeremy R Fondran; Jonathan H Lass; Sheng Feng; Jing Hua Zhao; Kay-Tee Khaw; Nick J Wareham; Taina Rantanen; Jaakko Kaprio; Chi Pui Pang; Li Jia Chen; Pancy O Tam; Vishal Jhanji; Alvin L Young; Angela Döring; Leslie J Raffel; Mary-Frances Cotch; Xiaohui Li; Shea Ping Yip; Maurice K H Yap; Ginevra Biino; Simona Vaccargiu; Maurizio Fossarello; Brian Fleck; Seyhan Yazar; Jan Willem L Tideman; Milly Tedja; Margaret M Deangelis; Margaux Morrison; Lindsay Farrer; Xiangtian Zhou; Wei Chen; Nobuhisa Mizuki; Akira Meguro; Kari Matti Mäkelä Journal: Nat Commun Date: 2016-03-29 Impact factor: 14.919