| Literature DB >> 25823570 |
Masahiro Miyake1,2, Kenji Yamashiro1, Yasuharu Tabara2, Kenji Suda1, Satoshi Morooka1, Hideo Nakanishi1, Chiea-Chuen Khor3,4,5,6, Peng Chen3, Fan Qiao3, Isao Nakata1,2, Yumiko Akagi-Kurashige1,2, Norimoto Gotoh2, Akitaka Tsujikawa1, Akira Meguro7, Sentaro Kusuhara8, Ozen Polasek9, Caroline Hayward10, Alan F Wright10, Harry Campbell11, Andrea J Richardson12, Maria Schache12, Masaki Takeuchi7,13, David A Mackey12,14, Alex W Hewitt12, Gabriel Cuellar15, Yi Shi16, Luling Huang16, Zhenglin Yang16,17,18, Kim Hung Leung19, Patrick Y P Kao20, Maurice K H Yap20, Shea Ping Yip19, Muka Moriyama21, Kyoko Ohno-Matsui21, Nobuhisa Mizuki7, Stuart MacGregor15, Veronique Vitart10, Tin Aung4,22, Seang-Mei Saw3,4,22, E-Shyong Tai3,23,24, Tien Yin Wong4,21,22, Ching-Yu Cheng4,22,24, Paul N Baird12, Ryo Yamada2, Fumihiko Matsuda2, Nagahisa Yoshimura1.
Abstract
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.Entities:
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Year: 2015 PMID： 25823570 DOI： 10.1038/ncomms7689
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919