Literature DB >> 23935264

The new biology: a bridge to clinical cardiology.

Ge Louridas1, Kg Lourida.   

Abstract

The recent advances in the biological research have produced new biological disciplines with clinical applications in medicine and cardiology. The integration of multilevel biological data and the connection with the clinical practice reveal the potential of personalized medicine and nanotechnology with future implications for prognosis, diagnosis and management. In the post-genomic time period the new disciplines, systems biology, synthetic biology and translational medicine are emerging as significant research areas in biology and medicine with extension in the field of clinical medicine and cardiology. These disciplines, with their predictive, preventive and therapeutic potential, are formulating the concept of personalized management, with patient's energetic involvement and participation in the diagnosis and treatment. Personalized medicine and cardiology, using biomarkers as health and disease indicators, encourage drug development and direct towards a better molecular comprehension of disease processes.

Entities:  

Keywords:  personalized cardiology; review; synthetic biology; systems biology; translational cardiology

Year:  2012        PMID: 23935264      PMCID: PMC3738410     

Source DB:  PubMed          Journal:  Hippokratia        ISSN: 1108-4189            Impact factor:   0.471


  82 in total

1.  A genomic view of alternative splicing.

Authors:  Barmak Modrek; Christopher Lee
Journal:  Nat Genet       Date:  2002-01       Impact factor: 38.330

Review 2.  Network biology: understanding the cell's functional organization.

Authors:  Albert-László Barabási; Zoltán N Oltvai
Journal:  Nat Rev Genet       Date:  2004-02       Impact factor: 53.242

Review 3.  Systems biology: an approach.

Authors:  P Kohl; E J Crampin; T A Quinn; D Noble
Journal:  Clin Pharmacol Ther       Date:  2010-06-09       Impact factor: 6.875

Review 4.  Molecular cardiology and genetics in the 21st century--a primer.

Authors:  Robert Roberts; Michael Gollob
Journal:  Curr Probl Cardiol       Date:  2006-10       Impact factor: 5.200

Review 5.  Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

Authors:  Jan van der Greef; Thomas Hankemeier; Robert N McBurney
Journal:  Pharmacogenomics       Date:  2006-10       Impact factor: 2.533

Review 6.  Predict, prevent and personalize: Genomic and proteomic approaches to cardiovascular medicine.

Authors:  Maral Ouzounian; Douglas S Lee; Anthony O Gramolini; Andrew Emili; Masahiro Fukuoka; Peter P Liu
Journal:  Can J Cardiol       Date:  2007-08       Impact factor: 5.223

7.  Unraveling myths of platelet function and genetic testing the road to making tailored antiplatelet therapy a reality.

Authors:  Dominick J Angiolillo
Journal:  J Am Coll Cardiol       Date:  2011-06-21       Impact factor: 24.094

8.  Physiology: alone at the bottom, alone at the top.

Authors:  Michael J Joyner
Journal:  J Physiol       Date:  2011-03-01       Impact factor: 5.182

9.  A grand challenge in biology.

Authors:  Bruce Alberts
Journal:  Science       Date:  2011-09-02       Impact factor: 47.728

10.  Cardiac gene expression profiling - the quest for an atrium-specific biomarker.

Authors:  A H Maass; A-M R De Jong; M D Smit; L Gouweleeuw; R A de Boer; W H Van Gilst; I C Van Gelder
Journal:  Neth Heart J       Date:  2010-12       Impact factor: 2.380

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  1 in total

Review 1.  The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics.

Authors:  Arwa M Amin; Lim Sheau Chin; Dzul Azri Mohamed Noor; Muhamad Ali Sk Abdul Kader; Yuen Kah Hay; Baharudin Ibrahim
Journal:  Cardiol Res Pract       Date:  2017-03-21       Impact factor: 1.866

  1 in total

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