BACKGROUND: Sporadic cases of parotitis are generally assumed to be mumps, which often requires a resource-intensive public health response. This project surveyed the frequency of viruses detected among such cases. METHODS: During 2009-2011, 8 jurisdictions throughout the United States investigated sporadic cases of parotitis. Epidemiologic information, serum, and buccal and oropharyngeal swabs were collected. Polymerase chain reaction methods were used to detect a panel of viruses. Anti-mumps virus immunoglobulin M (IgM) antibodies were detected using a variety of methods. RESULTS: Of 101 specimens, 38 were positive for a single virus: Epstein-Barr virus (23), human herpesvirus (HHV)-6B (10), human parainfluenza virus (HPIV)-2 (3), HPIV-3 (1), and human bocavirus (1). Mumps virus, enteroviruses (including human parechovirus), HHV-6A, HPIV-1, and adenoviruses were not detected. Early specimen collection did not improve viral detection rate. Mumps IgM was detected in 17% of available specimens. Patients in whom a virus was detected were younger, but no difference was seen by sex or vaccination profile. No seasonal patterns were identified. CONCLUSIONS: Considering the timing of specimen collection, serology results, patient vaccination status, and time of year may be helpful in assessing the likelihood that a sporadic case of parotitis without laboratory confirmation is mumps.
BACKGROUND: Sporadic cases of parotitis are generally assumed to be mumps, which often requires a resource-intensive public health response. This project surveyed the frequency of viruses detected among such cases. METHODS: During 2009-2011, 8 jurisdictions throughout the United States investigated sporadic cases of parotitis. Epidemiologic information, serum, and buccal and oropharyngeal swabs were collected. Polymerase chain reaction methods were used to detect a panel of viruses. Anti-mumps virus immunoglobulin M (IgM) antibodies were detected using a variety of methods. RESULTS: Of 101 specimens, 38 were positive for a single virus: Epstein-Barr virus (23), humanherpesvirus (HHV)-6B (10), humanparainfluenza virus (HPIV)-2 (3), HPIV-3 (1), and human bocavirus (1). Mumps virus, enteroviruses (including human parechovirus), HHV-6A, HPIV-1, and adenoviruses were not detected. Early specimen collection did not improve viral detection rate. Mumps IgM was detected in 17% of available specimens. Patients in whom a virus was detected were younger, but no difference was seen by sex or vaccination profile. No seasonal patterns were identified. CONCLUSIONS: Considering the timing of specimen collection, serology results, patient vaccination status, and time of year may be helpful in assessing the likelihood that a sporadic case of parotitis without laboratory confirmation is mumps.
Authors: Lina I Elbadawi; Pamela Talley; Melissa A Rolfes; Alexander J Millman; Erik Reisdorf; Natalie A Kramer; John R Barnes; Lenee Blanton; Jaime Christensen; Stefanie Cole; Tonya Danz; John J Dreisig; Rebecca Garten; Thomas Haupt; Beth M Isaac; Mary Anne Jackson; Anna Kocharian; Daniel Leifer; Karen Martin; Lisa McHugh; Rebecca J McNall; Jennifer Palm; Kay W Radford; Sara Robinson; Jennifer B Rosen; Senthilkumar K Sakthivel; Peter Shult; Anna K Strain; George Turabelidze; Lori A Webber; Meghan Pearce Weinberg; David E Wentworth; Brett L Whitaker; Lyn Finelli; Michael A Jhung; Ruth Lynfield; Jeffrey P Davis Journal: Clin Infect Dis Date: 2018-08-01 Impact factor: 9.079
Authors: Minesh Shah; Patricia Quinlisk; Andrew Weigel; Jacob Riley; Lisa James; James Patterson; Carole Hickman; Paul A Rota; Rebekah Stewart; Nakia Clemmons; Nicholas Kalas; Cristina Cardemil Journal: Clin Infect Dis Date: 2018-01-06 Impact factor: 9.079